Meaume et al. The importance of pain reduction through dressing selection in routine wound management: the MAPP study, Journal of Wound Care, 2004, Vol 13, No 10, 409-413.

Lozano Sanchez F. S., Marinel lo Roura J., Carrasco Carrasco E., Gonzalez-Porras J. R., Escudero Rodriguez J. R., Sanchez Nevarez I., et al.. (2014). Venous leg ulcer in the context of chronic venous disease. Phlebology 29, 220–226. 10.1177/0268355513480489 [ PubMed] [ CrossRef] [ Google Scholar] Sigal ML, Addala A, Maillard H, Chahim M, Sala F, Blaise S, Dalac S, Meaume S, Bohbot S, Tumba C, Tacca O. Clinical evaluation of a new TLC-NOSF dressing with poly-absorbent fibers for the local management of exuding leg ulcers, at the different stages of the healing process: Results from two multicentric, single-arm, prospective, open-label clinical trials. J Wound Care 2019: 28(3) :164-175 If clinical signs of local infection are noted, treatment can be changed to an antibacterial dressing dependent on clinical judgement. A large amount of exudate; prone to infection; severe cases can injure subcutaneous and submucosal tissuesIf required UrgoTul Absorb and UrgoTul Absorb Heel can be cut using sterile equipment to adjust the size of the dressing to fit the wound. Hobot J., Walker M., Newman G., Bowler P. (2008). Effect of hydrofiber wound dressings on bacterial ultrastructure. J. Electron Microsc. 57, 67–75. 10.1093/jmicro/dfn002 [ PubMed] [ CrossRef] [ Google Scholar] Meaume S, Truchetet F, Cambazard F et al. A randomized, controlled, double-blind prospective trial with a Lipido-Colloid Technology-Nano-OligoSaccharide Factor wound dressing in the local management of venous leg ulcers. Wound Repair Regen. 2012; 20: 4, 500–511. Benbow M. A clinical evaluation of Urgotul® to treat acute and chronic wounds. British Journal of Nursing. 2004. Vol 13, N°2: 105-109. Moura L. I., Dias A. M., Carvalho E., de Sousa H. C. (2013). Recent advances on the development of wound dressings for diabetic foot ulcer treatment–a review. Acta Biomater. 9, 7093–7114. 10.1016/j.actbio.2013.03.033 [ PubMed] [ CrossRef] [ Google Scholar]

UrgoClean Ag must not be used during hyperbaric oxygen chamber therapy without an oxygen mask (risk of combustion due to the presence of fat). This contraindication does not apply for hyperbaric oxygen chamber therapy with an oxygen mask if the oxygen concentration inside the chamber is less than 25% and if UrgoClean Ag is not applied on the area over which the mask is placed.Münter KC, Meaume S, Augustin M, Senet P, Kérihuel J.C. The reality of routine practice: a pooled data analysis on chronic wounds treated with TLC-NOSF wound dressings. J Wound Care. 2017 Feb; 26 (Sup2): S4-S15. Erratum in: J Wound Care. 2017 Mar 2; 26(3): 153 White R. Supporting evidence - based practice: a clinical review of TLC technology, J Wound Care 2015. Radiation increases the expression of apoptosis-related genes, retards cell proliferation, and decreases cytokine activity and collagen content, resulting in delayed wound healing (Zhang et al., 2012, 2014). A transparent film dressing can be used to protect the skin in the illuminated area. The film dressing using Airwall exhibited a satisfactory prophylactic effect (Arimura et al., 2016). CAV lll: in non-infected (IDSA/IWGDF infection criteria) neuro-ischaemic diabetic foot ulcers (non-critical ischaemia, in the granulation phase (sequential treatment)

Medihoney® HCS is an all in one dressing combining the unique properties of medical grade Manuka honey with a hydrogel sheet containing superabsorbent polymers. Hosiery appliances: there is currently no formulary for hosiery appliances. Please ensure that patients are using the most cost effective and clinically appropriate appliance following details in the Drug Tariff. Please see the link to the NHSBSA here for the latest version of the Drug Tariff Raffetto J. D. (2009). Dermal pathology, cellular biology, and inflammation in chronic venous disease. Thromb. Res. 123( Suppl. 4), S66–S71. 10.1016/S0049-3848(09)70147-1 [ PubMed] [ CrossRef] [ Google Scholar] National Institute for Health and Care Excellence (NICE), UrgoStart for treating leg ulcers and diabetic foot ulcers, https://www.nice.org.uk/guidance/mtg42, April 2023 Jeffcoate W. J. (2012). Wound healing–a practical algorithm. Diabetes Metab. Res. Rev. 28( Suppl. 1), 85–88. 10.1002/dmrr.2235 [ PubMed] [ CrossRef] [ Google Scholar]Hold secondary dressing in place with a conforming bandage, adhesive tape or an elasticated tubular bandage. The chronic nature of venous leg ulcers is characterised by three measures: (i) the duration of the ulceration, (ii) ulcer recurrence and (iii) the period of time since the onset of the first ulceration to the time of the survey 2, 3. Reports from studies in Western countries on the duration of leg ulcers indicate that more than 50% last longer than 1 year 2, 7, 8. Results of data collected on the ulcer prevalence indicate that between 28% and 45% of individuals with leg ulcers experience episodes of leg ulcers for more than 10 years 2, 3.

Bioactive dressing promoted angiogenesis in DFU. (A) Synthesis and biological function of the fluorinated ethylenepropylene (FEP) hydrogel scaffold containing exosomes. (B) Immunofluorescence images of the wound bed stained withα-smooth muscle actin(α-SMA) at day 7. (C) The number of new blood vessels at day 7. (D) Images of wound healing in mice in different groups. (E) Wound closure rate in different groups during wound healing ( ** P< 0.01). Reproduced with permission from Wang et al. ( 2019). In the absence of specific clinical data, the use of the UrgoClean Ag dressing during pregnancy or breastfeeding or in newborn or premature babies is not recommended.at System.Web.Mvc.Html.PartialExtensions.Partial(HtmlHelper htmlHelper, String partialViewName, Object model) It is generally accepted that wounds heal faster in a moist wound environment (19). Modern wound dressings have been designed to promote these conditions. This type of dressing interacts with the wound exudate, providing a non adherent layer between the wound and the dressing. This moist layer not only protects the wound from mechanical damage, but also sequesters and immobilises bacteria (20), and provides an optimal environment for the wound to heal (21). Venous leg ulcers (VLU) are chronic ulcers caused by excessive venous pressure in the lower extremities and abnormal venous blood flow, eventually leading to the formation of an ulcer on the skin of the lower leg (Palfreyman et al., 2007; Chapman, 2017). It is one of the clinical manifestations of chronic venous insufficiency at the most severe stage. The underlying causes of the disease are venous valve incompetence and calf muscle pump insufficiency, leading to venous stasis and hypertension (Gianfaldoni et al., 2017). In this case, the local blood circulation is altered, and the blood supply to the local tissue is insufficient (Serra et al., 2016). Prolonged care leads to high treatment costs. Moreover, the quality of life of patients with chronic VLU is severely affected (Salome et al., 2016). Nuutila K., Singh M., Kruse C., Philip J., Caterson E. J., Eriksson E. (2016). Titanium wound chambers for wound healing research. Wound Repair Regen. 24, 1097–1102. 10.1111/wrr.12472 [ PubMed] [ CrossRef] [ Google Scholar]