The worsening crisis of MDR bacterial infections has heightened the interest in bacteriophage (phage) therapy. Phage therapy utilizes virulent (lytic) phages, which obligately kill their bacterial host whilst self-replicating during the lytic cycle of infection. Although there has been one report using genome engineering of lysogenic phages [ 5], until recently only lytic phages have been prioritised for therapy and explored for the treatment of wound infections. Advances in techniques used to engineer phages for therapy are reviewed elsewhere [ 6]. Phage therapy has regained attention due to its ability to kill bacteria regardless of their antibiotic-resistance profile [ 7]. The first report of phage therapy for surgical and wound infection was during the Finnish Campaign in 1939–1940. The soldiers were treated with a mix of Staphylococcus and Streptococcus phages prepared at the Eliava Institute of Bacteriophages, Microbiology and Virology in Tbilisi, Georgia. Phage therapy saved the lives of 83% of infected soldiers, compared with 58% using other treatment options [ 8]. Similarly, another report showed 81% survival in phage-treated soldiers and 46% survival in those on other medications [ 9]. Furthermore, mobile sanitary brigades were in operation to provide prophylactic treatment of wounds, which reduced the number of gas gangrene by 30% in three independent brigades [ 9]. Despite such an excellent treatment outcome, the use of phages was soon discontinued in the Western counties with the discovery of a broad-spectrum antibiotic, penicillin [ 10]. Fortunately, phages therapy was continuously practiced and improved in the Eastern European countries, particularly in Russia, Poland and Georgia. Over the past decade, phage therapy has regained traction in response to emergence of MDR bacteria. Now, there are a growing number of studies indicating that phage therapy could be a promising prospect for treating acute and chronic wound infections caused by MDR bacteria. Levin M. Pharmaceutical process scale-up [Internet]. Marcel Dekker; 2002 [cited 2018 Jan 11]. 566 p. Available from: https://books.google.nl/books/about/Pharmaceutical_Process_Scale_Up.html?id=-HBRzGQRpHkC&redir_esc=y. Lake OA, Hulshoff A, Indemans AWM (1982) Analysis of creams—III. Application of gas-liquid chromatography. Part I. Pharm Weekbl Sci Ed 4:43–48. https://doi.org/10.1007/BF01963660

Cetomacrogol cream | Healthify

Use a clean spoon or spatula to remove emollients from a pot or tub. This reduces the risk of infections from contaminated pots. Risk of slipping Anionic creams contain emulsifying agents that yield large anions and are therefore potentially incompatible with cationic drugs. An ion pair is likely to form between the anionic emulsifying agent and the cationic drug, and this can reduce either the efficacy of the emulsifying agent or the activity of the drug. Aqueous cream is a cream of this type. Cationic creams Hu J, Miyanaga K, Tanji Y. Diffusion properties of bacteriophages through agarose gel membrane. Biotechnol ProgRing J, Alomar A, Bieber T, et al. Guidelines for treatment of atopic eczema (atopic dermatitis) part I. J Eur Acad Dermatol Venereol 2012; 26: 1045–60. DOI: 10.1111/j.1468-3083.2012.04635.x. Journal Owing to the nature of the products being assessed, participants were not able to be blinded to the treatment arms. Jeffcoate WJ, Vileikyte L, Boyko EJ, Armstrong DG, Boulton AJM. Current challenges and opportunities in the prevention and management of diabetic foot ulcers. Diabetes care

Cetomacrogol - an overview | ScienceDirect Topics Cetomacrogol - an overview | ScienceDirect Topics

When applied to the skin, cetomacrogol works by providing a layer of oil on the surface of the skin, which traps water beneath it and prev Occlusive emollients consist of oils of non-human origin (wool-fat, mineral oil etc.), either in pure form or mixed with varying amounts of water through the action of an emulsifier to form a lotion or cream. A large variety are available, reflecting that there is no ‘right’ moisturiser for all patients; the most suitable one often having to be found by trial and error. Emollients are often used to help manage dry, itchy or scaly skin conditions such as eczema, psoriasis and ichthyosis. Fraser AJ, Tocher DR, Sargent JR (1985) Thin-layer chromatography—flame ionization detection and the quantitation of marine neutral lipids and phospholipids. J Exp Mar Bio Ecol 88:91–99. https://doi.org/10.1016/0022-0981(85)90204-7Carbol J, Tan PI, Varma Y, Osborne DW. Formulating topical products containing live microorganisms as the active ingredient. Pharm Technol The study was analysed by an intention to treat, with the participants who withdrew considered to be non-responders. The prespecified statistical analysis was logistic regression for the difference in proportions with response. In a post hoc analysis, the proportion of participants in whom the IGA-RSS score at week 8 was zero, (ie, full resolution of rosacea) was 9/68 (13.2%) and 2/69 (2.9%) in the Honevo and control groups, respectively, relative risk 4.6 (95%CI 1.0 to 20.4, p=0.031).

Emollients - NHS Emollients - NHS

Amplification and purification of T4-like escherichia coli phages for phage therapy: from laboratory to pilot scale. Appl Environ Microbiol Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Method: Melt the cetomacrogol emulsifying wax and white soft paraffin in the liquid paraffin. Add the chlorocresol to a warmed 200mL container, then add approximately 45mL of just-boiled purified water (>80°C), close the container and shake to dissolve. Add the glycerol to the aqueous phase, then mix both phases and stir until a semi-solid cream forms. Make up to 100g with warm purified water and mix thoroughly. Stir until cool.

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My 2month old was prescribed Epizone E for her dry skin. It works like a charm. I use Epizone A to bath her with then apply Epizone E after baths. It has no parabens, fragrance or colourants which is great. I also use it as a daily moisturizer Wound healing potential of topical bacteriophage therapy on diabetic cutaneous wounds. Wound Repair Regen Park EK, Song KW. Rheological evaluation of petroleum jelly as a base material in ointment and cream formulations: steady shear flow behavior. Arch Pharm Res. 2010;33(1):141–50. Shaikh R, Raj Singh TR, Garland MJ, Woolfson AD, Donnelly RF. Mucoadhesive drug delivery systems. J Pharm Bioallied Sci