Anti-epileptic drugs such as sodium valproate, gabapentinand pregabalin may also be of benefit to some patients, e.g., those with itch associated with renal failure or neuropathic itch. The mechanism of action is uncertain. Lotions are good for hairy or damaged areas of skin (such as weeping eczema – where pus is seeping out of damaged areas of skin). This is because lotions are thin and spread easily, but they're not very moisturising. Sprays The antifungal ingredient in this cream is called butenafine hydrochloride. It is used to treat both fungal and yeast infections, although this particular cream is not approved for the treatment of vaginal yeast infections. Pramoxine, which is thought to exert anti-pruritic effects by stabilizing membranes of sensory nerves, effectively decreases itch in patients with xerosis, uremic pruritus, and psoriasis and has been used as a single agent or in combination with mild potency topical steroids or lactic acid lotion. 15, 53– 55 In a randomized, double-blind, comparative trial in patients suffering from uremic pruritus, twice daily application of pramoxine 1% lotion for 4 weeks significantly reduced pruritus compared to a control lotion and was generally well-tolerated. 54 Non-steroidal creams: This category includes over-the-counter creams with moisture-enhancing ingredients like glycerin and complex ceramides, essential oils like menthol and camphor, and ingredients like pramoxine. These creams are a great first-choice for skin irritations and general dry skin itch.

In diabetes mellitus, localised itch tends to occur in the perianal/genital region usually due to Candida albicans or dermatophyte infections. It is unclear if metabolic abnormalities such as renal impairment, autonomic failure or diabetic neuropathy contribute to this. If pruritus is severe and sleep is disturbed treatment with oral medication may be necessary. Some drugs may help to relieve the itch whilst others are given solely for their sedative effects. Dr. Young also adds that anti-itch creams can help to relieve the itch associated with dry skin. “This is a year-round problem for many people, and it tends to get worse in the winter months from the cool, dry air.”

Who gets uraemic pruritus? 

You may also want to avoid synthetic materials and opt for natural ones, such as cotton, instead. These are "breathable" and allow the air to circulate close to your skin. Regular use of non-soap cleansers and applying emollients, such as cetomacrogol + glycerol or petrolatum several times daily Other measures that can be useful in preventing pruritus include avoiding precipitating factors such as rough clothing or fabrics, overheating, and vasodilators if they provoke itching (eg, caffeine, alcohol, spices). Fingernails should be kept short and clean. If the urge to scratch is irresistible then rub the area with your palm.

Emollients are best applied after washing your hands, taking a bath or showering because this is when the skin most needs moisture. In Hodgkin lymphoma, pruritus is thought to be caused by histamine release, which may be related to eosinophilia. Steroid-based creams: Hydrocortisone and other corticosteroid creams fall under this category. These creams are made for reducing inflammation associated with chronic or recurring skin conditions like psoriasis and eczema. You may or may not need a prescription, depending on the total amount of steroid active in the product. In some cases, you may want to consult with a dermatologist to determine which strength is best for your skin needs.When you get bitten by an insect, your immune system releases compounds called histimines. According to the American Academy of Allergy, Asthma & Immunology, histimines are chemicals released by the immune system when the body encounters an allergen—like a bug bite. When you apply an antihistamine, it reduces the allergic reaction. Tarikci N, Kocaturk E, Gungor S, Topal IO, Can PU, Singer R. Pruritus in systemic diseases: a review of etiological factors and new treatment modalities. Scientific World J [Internet]. 2015 Jun [cited 2016 June 29]; 2015. Available from: http://dx.doi.org/10.1155/2015/803752 A medicine called ursodeoxycholic acid (UDCA) can be prescribed to try to relive itching. But recent evidence suggests it may not be effective in reducing bile acids and easing itching.