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Tissues and Issues

Tissues and Issues

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Muscle tissue is both extensible and elastic. The cells are contractile and are highly organized into fiber bundles. Muscle is classified according to the appearance of the contractile cells, into three types: skeletal, cardiac and smooth. The first two types have a striated appearance due to the parallel orientation of the fiber bundles.

Koga, Y., Koga, T., Kinekawa, Y. & Kitabatake, N. Properties of a thermostable emulsion prepared from process whey protein and olive oil; use as a cream-substitute and its practical application to panna-cotta. J. Cook. Sci. Jpn 34, 154–163 (2001).

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Epithelial tissue is a highly cellular tissue that overlies body surfaces, lines cavities, and forms glands. It is avascular but innervated. Epithelial cells exist in close apposition, forming a barrier between connective tissues and free surfaces. Their surfaces face basally, apically and laterally, with each having distinctive features. Specialized epithelial tissue also exists.

Iskratsch, T., Wolfenson, H. & Sheetz, M. P. Appreciating force and shape — the rise of mechanotransduction in cell biology. Nat. Rev. Mol. Cell Biol. 15, 825–833 (2014). Wagenseil, J. E. & Mecham, R. P. Elastin in large artery stiffness and hypertension. J. Cardiovasc. Transl. Res. 5, 264–273 (2012). Haase, K. & Pelling, A. Investigating cell mechanics with atomic force microscopy. J. R. Soc. Interface 12, 20140970 (2015). Ogawa, S. et al. Relationship between liver tissue stiffness and histopathological findings analyzed by shear wave elastography and compression testing in rats with non-alcoholic steatohepatitis. J. Med. Ultrason. 43, 355–360 (2016). Hollister, S. J. & Lin, C. Y. Computational design of tissue engineering scaffolds. Comput. Methods Appl. Mech. Eng. 196, 2991–2998 (2007).

Danielsen, C. C. Tensile mechanical and creep properties of Descemet’s membrane and lens capsule. Exp. Eye Res. 79, 343–350 (2004). Pang, Z., Deeth, H., Sopade, P., Sharma, R. & Bansal, N. Rheology, texture and microstructure of gelatin gels with and without milk proteins. Food Hydrocoll. 35, 484–493 (2014). Gonzalez-Rodriguez, D., Guevorkian, K., Douezan, S. & Brochard-Wyart, F. Soft matter models of developing tissues and tumors. Science 338, 910–917 (2012).

Kaushik, G., Fuhrmann, A., Cammarato, A. & Engler, A. J. In situ mechanical analysis of myofibrillar perturbation and aging on soft, bilayered Drosophila myocardium. Biophys. J. 101, 2629–2637 (2011). Chu, S.-Y. et al. Mechanical stretch induces hair regeneration through the alternative activation of macrophages. Nat. Commun. 10, 1524 (2019).Costs of volunteer expenses, publicity and first aid kit etc for walking group out of community hub in Foxhole. Somlyo, A. P. et al. Ultrastructure, function and composition of smooth muscle. Ann. Biomed. Eng. 11, 579–588 (1983).

Cuboidal – cells are cube-shaped, can be found forming tubes in the nephrons of the kidney, involved in secretion and absorption Ryan, A. J. & O’Brien, F. J. Insoluble elastin reduces collagen scaffold stiffness, improves viscoelastic properties, and induces a contractile phenotype in smooth muscle cells. Biomaterials 73, 296–307 (2015). Yip, A. K. et al. Anisotropic traction stresses and focal adhesion polarization mediates topography-induced cell elongation. Biomaterials 181, 103–112 (2018). Chaudhuri, O. et al. Hydrogels with tunable stress relaxation regulate stem cell fate and activity. Nat. Mater. 15, 326–334 (2015). A seminal work on the effect of controlled 3D stress relaxation on the behaviour of stem cells.

Nervous tissue

Li, W. et al. Fibrin fiber stiffness is strongly affected by fiber diameter, but not by fibrinogen glycation. Biophys. J. 110, 1400–1410 (2016). Omari, E. A., Varghese, T., Kliewer, M. A., Harter, J. & Hartenbach, E. M. Dynamic and quasi-static mechanical testing for characterization of the viscoelastic properties of human uterine tissue. J. Biomech. 48, 1730–1736 (2015). Lee, J. K. et al. Tension stimulation drives tissue formation in scaffold-free systems. Nat. Mater. 16, 864–873 (2017). Agache, P. G., Monneur, C., Leveque, J. L. & De Rigal, J. Mechanical properties and Young’s modulus of human skin in vivo. Arch. Dermatol. Res. 269, 221–232 (1980). Tan, J. L. et al. Cells lying on a bed of microneedles: an approach to isolate mechanical force. Proc. Natl Acad. Sci. USA 100, 1484–1489 (2003).



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