Recce, M. & O'Keefe, J. The tetrode: a new technique for multi-unit extracellular recording. Soc. Neurosci. Abstr. 15, 1250 (1989). El Lakhrach, H., Hattour, A., Jarbouio, O., Elhasni, K. & Ramos-Espala, A. A. Spatial distribution and abundance of the megabenthic fauna community in Gabes Gulf (Tunisia, eastern Mediterranean Sea). Mediterr. Mar. Sci. 13, 12–29 (2012). Stability: Normalized Root Mean Square ( nRMS) of the acceleration measured at pelvis, trunk, and head levels. The values were obtained for the AP, ML, and CC signal components as well as the magnitude value. High nRMS values have been associated with higher levels of acceleration, and hence, decreased stability [ 42];

Analyzing the relationship between gamma power (amplitude of the complex Hilbert transform) and theta phase confirmed that the largest gamma power was associated with the descending phase of theta oscillations in the CA1 pyramidal layer during both RUN and REM ( Fig. 2 C) ( Buzsáki et al., 2003; Csicsvari et al., 2003; Colgin et al., 2009). In contrast, the maximum power of fast gamma (epsilon, ϵ) occurred at the trough of the theta cycle during RUN and shifted to the peak during REM, largely reflecting the maximum firing probability of pyramidal neurons ( Fig. 2 B) ( Montgomery et al., 2008). These findings indicate that the mechanisms by which the different gamma bands are modulated by theta oscillations are state dependent. Roberto Bellini, Chief Executive Officer of BELLUS, said: “This acquisition recognises the value of our highly selective P2X3 antagonist camlipixant and validates the hard work and dedication of all the BELLUS employees in advancing camlipixant to date. As a leader in respiratory research for over five decades, GSK shares our commitment to bettering the lives of individuals suffering from a persistent cough and is the ideal Company to rapidly bring camlipixant to the millions suffering from refractory chronic cough around the world.” From a neurorehabilitative point of view, our results could help with the management of patients with sTBI for two important reasons: (i) gait and balance instrumental evaluation should be performed during more ecological and challenging contexts that consider curved walking as a condition more representative of real-life scenarios; (ii) a neurorehabilitation program could be tailored according to the results of instrumental assessments [ 52]. In this respect, our work is in line with very recent trends observed in the literature that progressively propose the joint use of wearables to objectify rehabilitation-driven movement changes and the adoption of motor tasks involving rotations to challenge the musculoskeletal system in motion. This approach is preferrable when aiming at identifying postural instability and could be also prospectively implemented into software applications that calculate IMU-based parameters in real-time and with a low computational cost [ 53]. It is always difficult saying goodbye to someone we love and cherish. Family and friends must say goodbye to their beloved Joseph A. Belluscio Jr. of Everett, Massachusetts, who passed away at the age of 61, on September 25, 2022. You can send your sympathy in the guestbook provided and share it with the family. Pergent-Martini, C. et al. Mapping of coastlines of the Republic of Cyprus, Progress report. 38 pp. (GIS Posidonie, 2013).Maiorano, P. et al. Bioecological study of the benthic communities on the soft bottom of the Vlora Gulf (Albania). J. Coastal Res. 58, 95–105 (2011). RCC is a cough that persists for more than eight weeks despite optimal treatment of any underlying conditions or where there is no identifiable underlying cause. 6 Cough hypersensitivity syndrome – excessive coughing, often in response to relatively innocuous stimuli – is now identified as the primary pathology in RCC. RCC is a frequent, yet often under-recognised, medical condition with significant physical, social, and psychological consequences on a patient’s quality of life. Two-thirds of patients are women averaging between 50-60 years old. 7 There are currently no approved treatments for this condition in the US or the EU. About camlipixant

Serra, I. A. et al. Genetic structure in the Mediterranean seagrass Posidonia oceanica: disentangling past vicariance events from contemporary patterns of gene flow. Mol. Ecol. 19, 557–568 (2010). John Belushi's body being taken from a bungalow at Chateau Marmont in Hollywood to the coroner's office after his death.; Photo: Getty Images Csicsvari, J. et al. Massively parallel recording of unit and local field potentials with silicon-based electrodes. J. Neurophysiol. 90, 1314–1323 (2003). Belushi’s wife, Judy, who he married in 1976, had remained at their residence in New York and had heard little from her husband in his final week. They spoke on March 4 and she recalled he sounded better – more frustrated than depressed – but she knew his drug use was out of control, according to the 1984 biography Wired: The Short Life and Fast Times of John Belushi by Bob Woodward.Arnaud-Haond, S. et al. Implications of extreme life span in clonal organisms: millenary clones in meadows of the threatened seagrass Posidonia oceanica. PLoS One 7, e30454 (2012). Swindale, N.V. & Spacek, M.A. Spike sorting for polytrodes: a divide and conquer approach. Front. Syst. Neurosci. 8, 6 (2014). Hill, D.N., Mehta, S.B. & Kleinfeld, D. Quality metrics to accompany spike sorting of extracellular signals. J. Neurosci. 31, 8699–8705 (2011). Camlipixant is an investigational, twice-daily oral P2X3 receptor antagonist for the treatment of RCC, which is currently being evaluated in the CALM phase III clinical development programme. Given the need for novel and effective medicines for RCC, camlipixant has the potential to be a breakthrough in the treatment landscape.

BELLUS is a late-stage biopharmaceutical company working to better the lives of patients suffering from persistent cough. About GSK in respiratory The results of our work showed that the regression of meadows is a generalised phenomenon in the Mediterranean Sea, even though some exceptions exist (e.g. Corsica, parts of the Sardinian coastline and the Valencia region in Spain).Bouveyron, C. & Brunet-Saumard, C. Model-based clustering of high-dimensional data: a review. Comput. Stat. Data Anal. 71, 52–78 (2014). Pillow, J.W., Shlens, J., Chichilnisky, E.J. & Simoncelli, E.P. A model-based spike sorting algorithm for removing correlation artifacts in multi-neuron recordings. PLoS One 8, e62123 (2013). From an applied biomechanics perspective, this work promotes the adoption of integrated instrumented approaches to motor performance assessment. The abundance of main effects for session, in both instrumented locomotion tasks, highlights how the IMU-based biomarkers could support the evaluation of the efficacy of the rehabilitative treatment, whether it is conventional or vestibular. The added value of our instrumented protocol is in the fact that we can go far beyond a global collective score (as happens in the clinical tests), giving the clinician the opportunity to objectively examine subtle improvements in gait quality from different domain perspectives (such as gait stability and smoothness, for instance).