Best Naturals Inositol 1000 mg 60 Tablets

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Myo-inositol has shown statistically significant (but small) improvements in unwanted hair [ 29]. One study found that it helped about a third of women with hirsutism. More than half of the women studied also saw significant improvements in PCOS acne [ 30]. 6. Weight Loss Benefits are Small at Best L.C., et al., Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev, 2017. 11(11): p. Cd003053. Additionally, a 2017 meta-analysis found significant reductions in fasting insulin in those with PCOS. The researchers concluded that myoinositol has a beneficial effect in improving the metabolic health of people with this condition. Gestational diabetes

P.G., et al., Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome. A randomized study. Gynecol Endocrinol, 2013. 29(4): p. 375-9.

However, mild side effects have been reported with doses of 12 grams per day or higher. These include nausea, gas, difficulty sleeping, headache, dizziness and tiredness ( 36). Polycystic ovary syndrome (PCOS) is a condition that causes hormone imbalances in women, which may lead to irregular periods and infertility. Weight gain, high blood sugar and undesirable cholesterol and triglyceride levels are also concerns with PCOS ( 16). The addition of folic acid to inositol supplements should be viewed with particular caution. Several recent studies have associated PCOS with MTHFR gene mutations [ 54, 55]. For these women, taking folic acid during pregnancy can affect childhood lung function [ 56]. Supplementing with methyl folate, the active form of folate is generally advised for PCOS patients instead of folic acid [ 57].

E., et al., Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. Fertil Steril, 2009. 91(5): p. 1750-4. The Coronary Drug Project Research Group. Clofibrate and niacin in coronary heart disease. JAMA 1975;231:360-81. [ PubMed abstract] Niaspan and generic niacin ER, available as a prescription medicine, provides 500-1,000 mg extended-release nicotinic acid. It is used to treat high blood cholesterol levels. Niacin Intakes and StatusYan H, Ma L, Wang Z, Lin Z, Su J, Lu BR (2015) Multiple tissue-specific expression of rice seed-shattering gene SH4 regulated by its promoter pSH4. Rice 8:1–10 L., et al., Association of biochemical B₁₂ deficiency with metformin therapy and vitamin B₁₂ supplements: the National Health and Nutrition Examination Survey, 1999-2006. Diabetes Care, 2012. 35(2): p. 327-33.

Intake recommendations for niacin and other nutrients are provided in the Dietary Reference Intakes (DRIs) developed by an expert committee of the Food and Nutrition Board (FNB) at the National Academies of Sciences, Engineering, and Medicine [ 2]. DRI is the general term for a set of reference values used for planning and assessing nutrient intakes of healthy people. These values, which vary by age and sex, include the following: Gestational diabetes is a common problem within the PCOS community. This is where women who didn’t previously have diabetes, start having high blood sugar levels during pregnancy. Gestational diabetes is a serious condition. It increases the risk of several health complications both for the mother and for the baby. D. and R. Tal, Inositol Treatment and ART Outcomes in Women with PCOS. Int J Endocrinol, 2016. 2016: p. 1979654. Many vegetables, fruits, whole grains, and dairy products provide some niacin. Enriched grains are also a source of niacin. Up to 4 grams of inositol daily has been taken by pregnant women in studies without adverse effects, though more research is needed in this population ( 37, 38).

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Leung K, Quezada M, Chen Z, Kanel G, Kaplowitz N. Niacin-induced anicteric microvesicular steatotic acute liver failure. Hepatol Commun 2018;2:1293-8. [ PubMed abstract] R.F., et al., The feasibility of a diet which enhances inositol availability. Progress in Nutrition, 2021. 23(2): p. e2021078. Minto C, Vecchio MG, Lamprecht M, Gregori D. Definition of a tolerable upper intake level of niacin: a systematic review and meta-analysis of the dose-dependent effects of nicotinamide and nicotinic acid supplementation. Nutr Rev 2017;75:471-90. [ PubMed abstract] Though there is no official consensus on the most effective type and dosage, the following have appeared to be effective in research studies:

Anna, R., et al., Myo-Inositol for the Prevention of Gestational Diabetes Mellitus. A Brief Review. J Nutr Sci Vitaminol (Tokyo), 2019. 65(Supplement): p. S59-s61. J.C. and A. Dunaif, Should all women with PCOS be treated for insulin resistance? Fertil Steril, 2012. 97(1): p. 18-22. Chen C, Sun X, Duanmu H, Yu Y, Liu A, Xiao J, Zhu Y (2015) Ectopic expression of a Glycine soja myo-inositol oxygenase gene (GsMIOX1a) in Arabidopsis enhances tolerance to alkaline stress. PLoS ONE 10(6):e0129998 Santamaria A, Giordano D, Corrado F, Pintaudi B, Interdonato ML, Vieste GD, Benedetto AD, D'Anna R. One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome. Climacteric. 2012;15(5):490-5. doi:10.3109/13697137.2011.631063What’s more, preliminary research found that the combination of inositol and folic acid may promote ovulation in women with fertility issues from PCOS ( 20, 21). Niacin inadequacy usually arises from insufficient intakes of foods containing niacin and tryptophan. It can also be caused by factors that reduce the conversion of tryptophan to niacin, such as low intakes of other nutrients [ 2, 22]. The following groups are among those most likely to have inadequate niacin status. People with undernutrition In a year-long clinical study in 80 women with metabolic syndrome, 2 grams of inositol taken twice daily reduced blood triglyceride levels by an average 34% and total cholesterol by 22%. Improvements in blood pressure and blood sugar were also seen ( 24).