Persin is harmful to some animals — birds, rabbits, horses, and goats, just to name a few. However, there have been no reported cases of avocado poisoning in dogs and cats. The avocado pit itself can also be a choking hazard for both dogs and cats, so make sure these are disposed of safely. Avocados have multiple health benefits from reducing inflammation, shiny coat and providing a healthy source of fats. The confusion arises from the fact that avocados contain a substance called Persin. Persin is a substance found in the avocado pit, skin, bark, and leaves of certain varieties. We sometimes get asked this as there can be some confusion as to the safety of avocados for dogs. Avocado and avocado oil are ingredients that have proven to be both beneficial and safe for dogs. Over the years there has been misinformation and confusion regarding avocado safety for dogs and cats.