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Urinary tract health: Saw palmetto can help improve urinary tract symptoms related to BPH, such as frequent urination.

The berry extract is believed to inhibit the enzyme 5-alpha reductase, similar to pumpkin seed oil. Don’t use with: It may interfere with medications like birth control and anticoagulants. Consult your doctor before beginning any new supplements. What is Saw Palmetto? improvement from baseline in hair loss arrest and overall quality for the SP group versus placebo (11%) The most recent RCT tested the efficacy of a 100-mg SP-containing food supplement (Lambdapil®, ISDIN, Barcelona, Spain) on 35 men with AGA, for 6 months. Outcomes were measured via phototrichogram, where digital images evaluating hair volume and appearance were assessed by dermatologists through a 7-point clinical score scale. Further outcomes were also subjectively evaluated by study participants via completion of self-assessment surveys regarding perceived treatment efficacy. There was a 23.4% increase from the baseline anagen/telogen ratio. An additional 3.7% increase in total anagen hair percentage (vs. 0.8% decrease), and a 3.7% decrease in total telogen hair percentage (vs. 0.8% increase), was noted among the active SP cohort as compared to placebo at 6 months. Patients reported increased hair volume, improved quality of life (QOL), and enhanced self-perceived efficacy using the SP-containing tablet [ 21]. A prospective, noncomparative cohort tested the efficacy of a nutritional compound containing 300-mg SP taken twice daily for 6 months in 15 males with AGA and 15 females with either female-pattern hair loss (FPHL), severe TE, or stress and food-deficiency induced hair loss. Saw palmetto may help prevent androgenic alopecia — a type of hair loss also known as male and female pattern baldness in men and women, respectively.Pumpkin seed oil has traditionally been used in herbal medicine for its supposed health benefits, including potentially supporting hair growth and health.

Hair loss is associated with significant consequences affecting body image, self-esteem, emotional well-being, and QOL [ 35], possibly even leading to psychiatric morbidity such as anxiety and depression [ 36, 37]. While minoxidil and finasteride remain the only United States Food and Drug Administration (FDA)-approved and most widely used therapies for pattern hair loss [ 38], undesired side effects have prompted the search for alternative therapies [ 39]. SP is a key ingredient in many over-the-counter supplements marketed for hair regrowth; however, limited data exist to support its efficacy in various alopecias or to better delineate its side-effect profile. It grows in sandy soil and gets its name from the sharp, saw-like teeth on the stalks that attach the tree’s leaves to its stem. The saw palmetto tree produces dark berries that contain a large seed ( 1).The saw palmetto fruit has long been used by Native Americans for its nutritional, diuretic, sedative, aphrodisiac, and cough-reducing properties.

Clinical evidence regarding the efficacy of SP-containing products to treat hair loss is limited. SP has shown promising results in murine models, with hair regrowth mediated through transforming growth factor-β and mitochondrial signaling pathways [ 40]. Additionally, in vitro models have demonstrated SP's ability to inhibit inflammatory gene expression in human keratinocytes, suggesting a multifaceted mechanism for the treatment of AGA, in addition to its proposed antiandrogenic properties [ 41]. The mechanism in which SP instigates hair growth in TE is not entirely clear. A possible explanation may be secondary to its anti-inflammatory properties, or to β-sitosterol's purported angiogenic effects, stimulating vascular endothelial growth factor in vitro and promoting neovascularization in vivo [ 42].Further research is needed before saw palmetto can be considered a suitable way to treat or prevent prostate cancer. Regulating testosterone Patient-reported increase in hair volume, improved QOL, and perceived efficacy in the SP group only In a clinical study, 93% of users reported satisfactory results regarding reduced hair shedding and encouraged hair growth.

However, individual responses can vary, and these supplements should not be considered standalone treatments. I started taking SP extract 4 years ago. After 4 weeks i started getting terrible Testicular pain and lowered libido. At the time i didn't connect the dots so i kept taking it. The Testicular pain got so bad that i quit the saw palmetto. Priestap, H.A., Quirke, J.M.E., Houle, P. et al. Chem Nat Compd (2011) 47: 511. doi:10.1007/s10600-011-9983-4 http://link.springer.com/article/10.1007/s10600-011-9983-4 Several human studies have demonstrated modest hair regrowth using oral and topical SP-containing products among patients with AGA, FPHL, TE, and self-perceived hair thinning. Improvement in total hair count ranging from 3.4 to 27% [ 18, 29], increased hair density in up to 83.3% of patients [ 24], 60% improvement in overall hair quality [ 19], and stabilized disease progression among 52% of patients [ 20] were noted with use of various SP-containing oral supplements, topical lotions, and/or serums.However, more research is needed to fully understand their effects on hair health. Consult a healthcare provider before starting a new supplement regimen.