At this point in the letter, we come to some of the most helpful and well-loved verses in the Bible. Paul provides the antidote to worry: Don’t worry about anything, but in everything, through prayer and petition with thanksgiving, present your requests to God. Prayer is relational communication with God. It seeks to draw resources from the invisible spiritual realm into visible, physical reality. Every time we begin to worry, we should see that as a call from God telling us that it’s time to pray. This is an important principle: the more you worry, the less you pray. The more you pray, the less you worry.

Pulpit Commentary Verse 6. - Be careful for nothing; rather, as R.V., in nothing be anxious. Μέριμνα is anxious, distracting care. St. Paul does not wish his converts to be careless, but to be free from that over-anxiety about worldly things which might distract their thoughts from the service of God, and hinder their growth in holiness. Comp. 1 Peter 5:7, where the apostle bids us cast all our care ( μέριμνα) upon God. The thought of the Lord's nearness should lead us both to be forbearing in our relations to others, and also to keep ourselves free, as far as may be, from worldly anxieties. "He careth for us." But in everything by prayer and supplication with thanksgiving let your requests be made known unto God. "Curare et orare," says Bengel, "plus inter se pugnant quam aqua et ignis." In everything; in each emergency, little or great, as it arises, pray; cultivate the habit of referring all things, great or small, to God in prayer. The two words rendered "prayer" and "supplication" προσευχή and δέησις) occur together also in Ephesians 6:18; 1 Timothy 2:l and Ephesians 5:5. The first has been defined by Chrysostom and others as prayer to obtain a good; the second, prayer to avoid an evil Better, perhaps, as most modern commentators, προσευχή is the general word, covering the idea of prayer in its widest meaning; while δέησις is a special act of supplication for some particular object of need (see Trench, 'Synonyms of the New Testament,' sect. 51.). With thanksgiving. Thanksgiving is the necessary accompaniment of prayer; it ought never to be absent from our devotions; it springs out of that holy joy which St. Paul so constantly sets before us in this Epistle as the bounden duty of Christians. St. Paul himself is an example of constant thanksgiving. All his Epistles, except those to the Galatians, 1 Timothy, and Titus, open with a thanksgiving. In the dungeon at Philippi he and Silas "prayed and sang praises unto God" ( Acts 16:25). Our requests, the things for which we ask, are to be made known unto God; πρὸςτὸνΘεόν before God, in the presence of God, by prayer, the general converse of the soul with God; and by supplication, direct petitions for the supply of our necessities. Indeed, he knows our necessities before we ask; but we are encouraged to make them known before him, as Hezekiah took the letter of Sennacherib and spread it before the Lord. Being anxious for nothing means finding encouragement from those whose lives boast of God’s faithfulness. These godly examples serve to help us lay down our own lives for Christ, looking to Him as the prime example of humility and obedience ( Philippians 2:8). 4. Don’t be anxious — death is not the end. Be anxious for nothing, but in everything by prayer and petition with thanksgiving let your requests be made known to God. Philippians 4 tells us to be anxious for nothing, but instead to present our needs “by prayer and supplication with thanksgiving, let your requests be known to God.” Don't worry about anything, but pray about everything. With thankful hearts offer up your prayers and requests to God.Jesus promised that we would have trials in this life, but He also promised to be with us through it all. When we pray, we can feel His presence and know that He is walking with us through our difficulties. 3. Focus on God’s goodness implore Euodia and I implore Syntyche to be of the same mind in the Lord. 3 [a]And I urge you also, true companion, help these women who labored with me in the gospel, with Clement also, and the rest of my fellow workers, whose names are in the Book of Life. I pray for them. ( Q) I do not pray for the world but for those whom You have given Me, for they are Yours. 10 And all Mine are Yours, and ( R) Yours are Mine, and I am glorified in them. 11 ( S) Now I am no longer in the world, but these are in the world, and I come to You. Holy Father, ( T) keep [ d] through Your name those whom You have given Me, that they may be one ( U) as We are. 12 While I was with them [ e] in the world, ( V) I kept them in [ f] Your name. Those whom You gave Me I have kept; and ( W) none of them is [ g] lost ( X) except the son of [ h] perdition, ( Y) that the Scripture might be fulfilled. 13 But now I come to You, and these things I speak in the world, that they may have My joy fulfilled in themselves. 14 I have given them Your word; ( Z) and the world has hated them because they are not of the world, ( AA) just as I am not of the world. 15 I do not pray that You should take them out of the world, but ( AB) that You should keep them from the evil one. 16 They are not of the world, just as I am not of the world. 17 ( AC) Sanctify [ i] them by Your truth. ( AD) Your word is truth. 18 ( AE) As You sent Me into the world, I also have sent them into the world. 19 And ( AF) for their sakes I sanctify Myself, that they also may be sanctified by the truth. Jesus Prays for All Believers Strong's 1722: In, on, among. A primary preposition denoting position, and instrumentality, i.e. A relation of rest; 'in, ' at, on, by, etc.

This verse is a reminder that we need to trust God, even when we don’t understand what He is doing. His ways are higher than our ways and His thoughts are higher than our thoughts. We can’t always see the big picture, but we can trust that God knows what He is doing. Be anxious for nothing, but in everything, by prayer and petition, with thanksgiving, present your requests to God.In John 14:26, Jesus tells us that it is better for Him to return to heaven because the Holy Spirit will be with us and help us when we experience anxiety. He said, “But the Helper, the Holy Spirit, whom the Father will send in My name, He will teach you all things and bring to your remembrance all that I have said to you.”