Mouse Heart

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And then she must see through the smoke and mirrors, dodge the traps laid for her, and set her sights on exposing the true villain.

Here, we established a whole-embryo live-imaging method based on two-photon microscopy that allows whole-tissue tracking at cellular resolution. Our study applies whole-embryo live analysis of cardiac development at tissue level and with cellular resolution. Set in a fictional, historical reign of Queen Mary II, there was a swashbuckling, Victorian feel to this book which really created an atmospheric setting! It means that she can make connections, will outrun pursuers, and then show her Mouse Heart to those she cares for. D–E) Membrane-GFP labeling of typical cTnnT +FHF ( D) and cTnnT-SHF ( E) cells at longitudinal HT stage.

In addition, these results reveal the timing of the main phases of linear HT development; cc differentiation, formation of the open HT and dorsal closure ( Figure 4I).

I think Mouse's adventures will be lapped up by young readers (middle to upper Primary) who enjoy an exciting read and aren't afraid of a bit of murder and mayhem along the way. These studies and our observations, however, cannot discriminate whether this lineage allocation results from intrinsic differences between these lineages or it is due to their exposure to position-specific environments, especially as in our studies sister cells remain close neighbors. Figure 1C,D) and separate from the endoderm, while maintaining a basal lamina at the endocardial side (inset in Figure 1D and Figure 2D). Like a good Agatha Christie, the murder’s do not stop at the first, and I sensed each tragedy before they happened – such is the brilliance of Hitchcock’s storytelling. Estimation of splanchnic mesoderm displacement speed toward the midline from time-lapse analyses ( Figure 4F’, and Video 6) indicates a range of average speeds from 12 to 20 µm/hr (15.

These results are consistent with the single-cell tracking analysis and confirm that the SHF does not differentiate during linear HT morphogenesis. and other views suggest that the heart would form by a continuous differentiation process from a single population of cardiac precursors and only timing of recruitment would distinguish cells of the FHF and SHF ( Abu-Issa et al. Continuously overlooked, undermined and underestimated, it gave rise to a forthright hero to step out and save the day which added such a sense of joy and satisfaction to the final conclusion.