What about coffee’s other long-term benefits? There is some evidence that its mood-elevating effects can be beneficial over the long term. In a 2016 meta-analysis of observational studies, caffeine consumption was found to decrease the risk of depression, while a Finnish study from 2010 found a similar result with coffee. In the Finnish study, the connection was weaker when other caffeinated drinks were consumed – suggesting that there is something in coffee specifically that can affect mood. One theory is that it’s the antioxidants, as these tend to correlate with reduced stress overall. It’s important to note that coffee and tea contain other bioactive compounds (besides caffeine) that may also be beneficial. Summary But moderation is the key word here. Just think of the French novelist Honoré de Balzac, who called coffee 'a great power in my life' and was supposed to have imbibed 50 cups a day. Or the singer Robbie Williams, who at one point claimed to be drinking 20 cans of Red Bull and 36 double espressos daily. This kind of consumption is hardly conducive to health and well-being. If you are pregnant or breastfeeding, it’s a good idea to limit your intake of caffeine to 200mg per day. That is 1 espresso, or 2 instant coffees or 4 cups of tea. A review noted that those who drink the most coffee have up to a 29% lower risk of developing type 2 diabetes. Similarly, those who consume the most caffeine have up to a 30% lower risk ( 36).

According to Chinese legend, the Chinese emperor Shennong, reputed to have reigned in about 3000 BCE, inadvertently discovered tea when he noted that when certain leaves fell into boiling water, a fragrant and restorative drink resulted. [247] Shennong is also mentioned in Lu Yu's Cha Jing, a famous early work on the subject of tea. [248] For the general population of healthy adults, Health Canada advises a daily intake of no more than 400mg. [72] This limit was found to be safe by a 2017 systematic review on caffeine toxicology. [73] Children activehours:........xxxxxxxx........ - put 24 . or x characters - which indicate from hour 0 to hour 23 of the day. Caffeine willOn the other hand, some studies suggest that caffeinated beverages may worsen gastroesophageal reflux disease (GERD) in some people. This seems to be especially true of coffee ( 23, 24, 25). Chocolate derived from cocoa beans contains a small amount of caffeine. The weak stimulant effect of chocolate may be due to a combination of theobromine and theophylline, as well as caffeine. [237] A typical 28-gram serving of a milk chocolate bar has about as much caffeine as a cup of decaffeinated coffee. By weight, dark chocolate has one to two times the amount of caffeine as coffee: 80–160mg per 100g. Higher percentages of cocoa such as 90% amount to 200mg per 100g approximately and thus, a 100-gram 85% cocoa chocolate bar contains about 195mg caffeine. [221] Tablets No-Doz 100mg caffeine tablets Common causes of rhabdomyolysis include trauma, infection, drug abuse, muscle strain and bites from poisonous snakes or insects.

Caffeine sometimes increases the effectiveness of some medications, such as those for headaches. [159] Caffeine was determined to increase the potency of some over-the-counter analgesic medications by 40%. [160] Faudone G, Arifi S, Merk D (June 2021). "The Medicinal Chemistry of Caffeine". Journal of Medicinal Chemistry. 64 (11): 7156–7178. doi: 10.1021/acs.jmedchem.1c00261. PMID 34019396. S2CID 235094871.

Trimethyluric acid is a minor caffeine metabolite. [8] 7-Methylxanthine is also a metabolite of caffeine. [189] [190] Each of the above metabolites is further metabolized and then excreted in the urine. Caffeine can accumulate in individuals with severe liver disease, increasing its half-life. [191] In healthy children, moderate caffeine intake under 400mg produces effects that are "modest and typically innocuous". [74] [75] As early as six months old, infants can metabolize caffeine at the same rate as that of adults. [76] Higher doses of caffeine (>400mg) can cause physiological, psychological and behavioral harm, particularly for children with psychiatric or cardiac conditions. [74] There is no evidence that coffee stunts a child's growth. [77] The American Academy of Pediatrics recommends that caffeine consumption is not appropriate for children and adolescents and should be avoided. [78] This recommendation is based on a clinical report released by American Academy of Pediatrics in 2011 with a review of 45 publications from 1994 to 2011 and includes inputs from various stakeholders (Pediatricians, Committee on nutrition, Canadian Pediatric Society, Centers for Disease Control & Prevention, Food and Drug Administration, Sports Medicine & Fitness committee, National Federations of High School Associations). [78] For children age 12 and under, Health Canada recommends a maximum daily caffeine intake of no more than 2.5 milligrams per kilogram of body weight. Based on average body weights of children, this translates to the following age-based intake limits: [72] Age range Grosso G, et al. Coffee, caffeine, and health outcomes: An umbrella review. Annual Review of Nutrition. 2019; doi:10.1146/annurev-nutr-071816-064941.

Interestingly, cortisol levels were similar between regular and less frequent caffeine consumers, suggesting the compound may have the same effect on stress levels regardless of whether you drink it habitually ( 12). Longevity. Drinking coffee may decrease the risk of premature death by as much as 30%, especially for women and people with diabetes ( 39, 40).

Robiquet was one of the first to isolate and describe the properties of pure caffeine, [262] whereas Pelletier was the first to perform an elemental analysis. [263]

Coffee’s laxative effect has been attributed to the release of gastrin, a hormone the stomach produces that speeds up activity in the colon. What’s more, decaffeinated coffee has been shown to produce a similar response ( 19, 20, 21). Research has shown that while caffeine remains in your system for an average of five hours, the time period may range from one and a half hours to nine hours, depending on the individual ( 17).Gut health. Consuming 3 cups of coffee a day for as few as 3 weeks may increase the amount and activity of beneficial gut bacteria ( 52). Caffeine in a dose dependent manner increases alertness in both fatigued and normal individuals. [56] You can find out more about caffeine through the Alcohol and Drug Foundation— call their Drug Info and Advice Line on 1300 85 85 84.