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Severe bacterial infections such as sepsis, infection with one of the germs that cause meningitis (meningococcal disease).

A person with thrombocytopenia has a low platelet count. The following types of purpuric rash may develop due to thrombocytopenia: Thrombotic thrombocytopenic purpura Note the nature of the lesions - size, confluence, associated blisters (and what these contain: exudate, blood, pus). Purpura is common with typhus and can be present with meningitis caused by meningococci or septicaemia. In particular, meningococcus ( Neisseria meningitidis), a Gram-negative diplococcus organism, releases endotoxin when it lyses. Endotoxin activates the Hageman factor (clotting factor XII), which causes disseminated intravascular coagulation (DIC). The DIC is what appears as a rash on the affected individual. Purpura is the name given to the discolouration of the skin or mucous membranes due to haemorrhage from small blood vessels. There is a risk of internal bleeding with the vascular form, which could become life threatening. For this reason, doctors often consider it the most serious form of the condition.Disseminated intravascular coagulation (DIC): Your blood over clots because proteins that control blood clotting are overactive.

Lotti T, Benci M, Sarti MG, Teofoli P, Senesi C, Bonan P, etal. (1993). "Psychogenic purpura with abnormally increased tPA dependent cutaneous fibrinolytic activity". International Journal of Dermatology. 32 (7): 521–23. doi: 10.1111/j.1365-4362.1993.tb02840.x. PMID 8340191. S2CID 38433734. Inflamed blood vessels ( vasculitis) cause persistent and localised purpura with an erythematous inflammatory component. This may be palpable. Ecchymoses and external bleeding are uncommon. Immunosuppressive medicines (such as rituximab [Rituxan®] or azathioprine [Azasan®]) to stop your immune system from destroying platelets.

Classification of purpura

Purpura are classified as thrombocytopenic and nonthrombocytopenic purpura depending on whether you have a low platelet count. Thrombotic thrombocytopenic purpura Unlike other rashes, purpura will not change color or blanch when pressed. The rash can resemble tiny clusters of bruises. While the skin will not be itchy or painful in many cases, some tenderness or irritation may sometimes occur. Small purple spots on the skin, typically 4–10 millimeters (mm) in diameter, characterize purpura. Some people develop areas of spots 2 mm or even smaller. These are called petechiae. Some people develop larger patches of 1 centimeter (cm) or greater. These are called ecchymoses. Some people inherit two ADAMTS13 genes with a mutation, one from each parent. Changes to the ADAMTS13 gene can mean the enzyme it produces does not function properly. People with one copy of the mutated gene may not experience TTP-associated symptoms. Pseudoxanthoma elasticum (a condition affecting the elastic tissue of the blood vessels and other parts of the body).

Over time, reductions in subcutaneous fat and connective tissue and long-term sun exposure can lead to increased bruising of mature skin due to minor trauma. This is known as actinic purpura. Other names for this include solar purpura, senile purpura, traumatic purpura, and Bateman’s disease. There are also some new medications available. Hematologists who can offer a specific treatment plan should manage difficult-to-treat ITP. Treatment for other forms of purpura In rare cases, thrombocytopenic purpura that’s left untreated may cause a person to develop excessive bleeding in some part of their body. Excessive bleeding in the brain can lead to a fatal brain hemorrhage. Palpable purpura is purpura than can be felt, due to inflammation of the blood vessels ( vasculitis)Purpura may occur with either normal platelet counts (non-thrombocytopenic purpuras) or decreased platelet counts (thrombocytopenic purpuras). Platelets help maintain the integrity of the capillary lining as well as being important in the clotting process. As a general rule, purpura indicates a problem of the platelet system whilst a deficiency of clotting factors will cause haematomas or haemarthrosis as in haemophilia. Nevertheless, clotting factor deficiency must be considered. Purpuric rash symptoms [ 1, 2, 3] Thrombotic thrombocytopenic purpura is a rare condition that occurs when you don’t have enough of the enzyme ADAMTS13, which leads to excessive blood clotting. “Thrombotic” refers to blood clots and “thrombocytopenic” refers to low levels of platelets. Castor Oilis rich in ricinoleic acid and omega-6 fatty acids that deeply condition the hair, stimulating blood circulation and consequently initiating hair growth. It is a well-known ingredient that boosts hair growth at up to five times the usual rate and reduces dandruff.

Purpura isn’t a medical condition. Instead, it’s a sign of another condition. There’s usually nothing you can do to reduce your risk. Specific risk factors for purpura are: A person with nonthrombocytopenic purpura has platelet levels in a normal range. The cause of purpura isn’t related to your platelet level. Decomposition of blood vessels including purpura is a symptom of acute radiation poisoning in excess of 2 Grays of radiation exposure. This is an uncommon cause in general, but is commonly seen in victims of nuclear disaster. Treating purpura involves identifying and stopping the underlying cause of the bleeding. Sometimes, treatment isn’t needed and the purpura goes away on its own. Once your healthcare provider determines the cause, they can: The term 'purpura' describes a purplish discolouration of the skin that is produced by small bleeding vessels near the surface. Purpura may also occur in the mucous membranes, especially of the mouth and in the internal organs. Purpura is not a disease per se but is indicative of an underlying cause of bleeding.

Some forms of skin cancer look similar to the purple spots of purpura. A biopsy can rule out skin cancer. Immune thrombocytopenic purpura (ITP) occurs when the body produces antibodies against its own platelet or clotting factor membrane proteins.