Adults who are at risk of vitamin D deficiency should take a daily supplement of 10 micrograms of vitamin D, throughout the year. Very good! Vitamin D is essential to your overall health and making sure you get enough is paramount to your well-being. Before you get started, it is important to know that there are different types of vitamin D: vitamin D3 and vitamin D2. Adequate calcium and regular exercise may help to achieve strong bones in children and adolescents and may reduce the risk of osteoporosis in older adults. An adequate intake of vitamin D is also necessary." [112] Everyone can benefit from taking colecalciferol as a daily vitamin D supplement. Adults who are not at risk of vitamin D deficiency should consider taking a daily supplement of 10 micrograms of vitamin D during autumn and winter. Low circulating vitamin D levels have been associated with lower total testosterone levels in males. Vitamin D supplementation could potentially improve total testosterone concentration, although more research is needed. [27] Other diseases [ edit ]

Your skin is your largest organ and vitamin D is critical to its health. The active form of Vitamin D (calcitriol) helps with skin repair and growth. Vitamin D3 is the precursor to Calcitriol. As you get older your body loses the ability to produce D3 which leads to a weaker immune system and weaker skin. 3) Healthy Muscles The active UVB wavelengths are present in sunlight, and sufficient amounts of cholecalciferol can be produced with moderate exposure of the skin, depending on the strength of the sun. [38] Time of day, season, latitude, and altitude affect the strength of the sun, and pollution, cloud cover or glass all reduce the amount of UVB exposure. Exposure of face, arms and legs, averaging 5–30 minutes twice per week, may be sufficient, but the darker the skin, and the weaker the sunlight, the more minutes of exposure are needed. Vitamin D overdose is impossible from UV exposure; the skin reaches an equilibrium where the vitamin degrades as fast as it is created. [38] Cholecalciferol can be produced in skin from the light emitted by the UV lamps in tanning beds, which produce ultraviolet primarily in the UVA spectrum, but typically produce 4% to 10% of the total UV emissions as UVB. Levels in blood are higher in frequent users of tanning salons. [38] Photochemistry [ edit ] The photochemistry of vitamin D biosynthesis in animal and fungi Thermal isomerization of previtamin D 3 to vitamin D 3

Speaking with your doctor can help determine the right amount of vitamin D for you. Blood samples are needed to run a 25-hydroxy (or 25-OH) vitamin D test. This blood test is best way to determine how much Vitamin D is in your body. Holland & Barrett Vitamin D3 contributes towards the maintenance of normal bones, muscle function and the immune system.

Liquid products, chewable tablets, or dissolving tablets may contain sugar and/or aspartame. Liquid products may also contain alcohol. Caution is advised if you have diabetes, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely. Synthesis of vitamin D in nature is dependent on the presence of UV radiation and subsequent activation in the liver and in the kidneys. Many animals synthesize vitamin D 3 from 7-dehydrocholesterol, and many fungi synthesize vitamin D 2 from ergosterol. [134] [168] Interactive pathway [ edit ] Kocher DK, Kaur G, Banga HS, Brar RS (2010). "Histopathological Changes in Vital Organs of House Rats Given Lethal Dose of Cholecalciferol (Vitamin D3)". Indian Journal of Animal Research. 2 (3): 193–6. ISSN 0367-6722. Use of cholecalciferol as a rodenticide in bait lowered the risk of secondary poisoning and minimized the toxicity of non-target species Just 3 ounces of rainbow trout provides 645 IU for 81% of the DV. It is also rich in heart-healthy omega-3 fatty acids.a b Ross AC, Taylor CL, Yaktine AL, Del Valle HB, etal. (Institute of Medicine (US); Committee to Review Dietary Reference Intakes for Vitamin D and Calcium) (2011). Dietary Reference Intakes for Calcium and Vitamin D (PDF). doi: 10.17226/13050. ISBN 978-0-309-16394-1. PMID 21796828. S2CID 58721779. Vitamin D overdose causes hypercalcemia, which is a strong indication of vitamin D toxicity – this can be noted with an increase in urination and thirst. If hypercalcemia is not treated, it results in excess deposits of calcium in soft tissues and organs such as the kidneys, liver, and heart, resulting in pain and organ damage. [24] [29] [167] Getting enough vitamin D helps your body to lose fat while building muscle and strength. Studies have also found that those deficient in vitamin D may experience chronic muscle pain, achiness, and fatigue. 4) Diabetes The EFSA reviewed safe levels of intake in 2012, [118] setting the tolerable upper limit for adults at 100 μg/day (4000 IU), a similar conclusion as the IOM. Because Vitamin D and calcium are related too much Vitamin D can lead to Calcium issues. These issues include, Hypercalcemia, Kidney Stones and Kidney damage.

Studies have found that those not getting enough vitamin D have a more difficult time managing their diabetes. Getting enough vitamin D can potentially help diabetes patients better manage their diabetes by helping to regulate glucose levels. Current research suggests that maintaining adequate levels of vitamin D also helps prevent the development of both types of diabetes. 5) Influenza Various institutions have proposed different recommendations for the amount of daily intake [119] of vitamin D. These vary according to precise definition, age, pregnancy or lactation, and the extent assumptions are made regarding skin synthesis of vitamin D. [115] [58] [116] [114] [117]If you are taking the chewable tablet or wafers, chew the medication thoroughly before swallowing. Do not swallow whole wafers. Hydroxylation in the endoplasmic reticulum of liver hepatocytes of cholecalciferol to calcifediol (25-hydroxycholecalciferol) by 25-hydroxylase is loosely regulated, if at all, and blood levels of this molecule largely reflect the amount of cholecalciferol produced in the skin combined with any vitamin D 2 or D 3 ingested.

While it’s possible to consume too much vitamin D3, it’s rare. “Vitamin D toxicity from supplementation exists but you have to try really, really, really hard,” says Dr. White. “For example, there are clinical trials where patients are given 100,000 to even 600,000 IUs (International Units) in bolus doses without side effects.”

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/ tongue/throat), severe dizziness, trouble breathing. Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, etal. (March 2007). "Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis". American Journal of Preventive Medicine (Meta-Analysis). 32 (3): 210–6. doi: 10.1016/j.amepre.2006.11.004. PMID 17296473. There are conflicting reports concerning the relative effectiveness of cholecalciferol (D 3) versus ergocalciferol (D 2), with some studies suggesting less efficacy of D 2, and others showing no difference. There are differences in absorption, binding and inactivation of the two forms, with evidence usually favoring cholecalciferol in raising levels in blood, although more research is needed. [23] Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, etal. (January 2011). "The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know". The Journal of Clinical Endocrinology and Metabolism. 96 (1): 53–8. doi: 10.1210/jc.2010-2704. PMC 3046611. PMID 21118827.