Zidovudine: Increased risk of haematological toxicity when NSAIDs are given with zidovudine. There is evidence of an increased risk haemarthroses and haematoma in HIV (+) haemophiliacs receiving concurrent treatment with zidovudine and ibuprofen. For more information, including what to do if you have any side effects, see Section 6. Are there any side effects? in the full CMI. Hazardous and harmful use. Nurofen Plus contains the opioid codeine and is a potential drug of abuse, misuse and addiction. Addiction can occur in patients appropriately prescribed Nurofen Plus at recommended doses. Treatment of perioperative pain in setting of coronary artery bypass surgery (CABG). 4.4 Special Warnings and Precautions for Use

Diarrhoea caused by pseudomembranous colitis or poisoning (until the causative organism or toxin has been eliminated from the gastrointestinal tract, since codeine may slow down the elimination, thereby prolonging the diarrhoea). Use with concomitant NSAIDs, including cyclo-oxygenase-2 specific inhibitors - increased risk of adverse reactions. From the 20th week of pregnancy onward, Nurofen use may cause oligohydramnios resulting from foetal renal dysfunction. This may occur shortly after treatment initiation and is usually reversible upon discontinuation. In addition, there have been reports of ductus arteriosus constriction following treatment in the second trimester, most of which resolved after treatment cessation. Therefore, during the first and second trimester of pregnancy, Nurofen should not be given unless clearly necessary. If Nurofen is used by a woman attempting to conceive, or during the first and second trimester of pregnancy, the dose should be kept as low and duration of treatment as short as possible. Antenatal monitoring for oligohydramnios and ductus arteriosus constriction should be considered after exposure to Nurofen for several days from gestational week 20 onward. Nurofen should be discontinued if oligohydramnios or ductus arteriosus constriction are found.

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During the third trimester of pregnancy, all prostaglandin synthesis inhibitors may expose the foetus to:

Always take ibuprofen tablets, capsules, granules and liquid with food or a drink of milk to reduce the chance of an upset stomach. Do not take it on an empty stomach. Do not take this medicine if you are allergic to any of these ingredients. What Nurofen Plus looks like In serious poisoning metabolic acidosis may occur and the prothrombin time/INR may be prolonged, probably due to interference with the actions of circulating clotting factors. Acute renal failure and liver damage may occur. The usual dose of Nurofen Plus is 2 tablets then, if necessary 1 or 2 tablets every 4 to 6 hours. Do not take more than six tablets in 24 hours.Concomitant treatment with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping treatment. Always follow your doctor or pharmacist's advice, and the instructions that come with your medicine. Dosage and strength for tablets, capsules, granules and liquid