Please read the included leaflet carefully before using this product and if you have any questions please contact one of our pharmacist for more information. Patients appear to be at highest risk of these reactions early in the course of therapy, the onset of the reaction occurring in the majority of cases within the first month of treatment.

overdose Paracetamol can cause acute hepatic failure, hepatic failure, hepatic necrosis and liver injury (see Section 4.Frequencies are defined as: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000), very rare (<1/10,000) and not known (cannot be estimated from the available data). Mifepristone: NSAIDs should not be used for 8-12 days after mifepristone administration as NSAIDs can reduce the effect of mifepristone. The administration of NSAIDs may cause a dose dependent reduction in prostaglandin formation and precipitate renal failure.

In addition, consideration was given to the following issues: The risk that a person may confuse the product with paracetamol alone and take the standard paracetamol dose of 2 tablets four times a day. Antiplatelet agents and selective serotonin reuptake inhibitors (SSRIs): Increased risk of gastrointestinal bleeding (see section 4. Patients who present with serious hepatic dysfunction beyond 24 hours from ingestion should be managed in accordance with established guidelines. Note that the NHS Digital SNOMED CT Browser is updated in line with the SNOMED CT UK Edition release schedule, and will therefore not always align with content in the latest SNOMED CT International Edition release. Conventional studies using the currently accepted standards for the evaluation of toxicity to reproduction and development are not available.From the 20th week of pregnancy onward, Ibuprofen use may cause oligohydramnios resulting from foetal renal dysfunction. signs of a severe allergic reaction (swelling of the face, tongue, or throat, difficulty breathing, worsening of asthma). Appropriate monitoring and medical advice are required for patients with a history of hypertension and/or mild to moderate congestive heart failure as fluid retention, hypertension and oedema have been reported in association with NSAID therapy. Care is advised in the administration of Paracetamol to patients with severe renal or severe hepatic impairment.