F. Bogazzi, L. Bartalena, E. Martino, Approach to the patient with amiodarone-induced thyrotoxicosis. J. Clin. Endocrinol. Metab. 95(6), 2529–2535 (2010). https://doi.org/10.1210/jc.2010-0180 S. Sato, J.Y. Noh, S. Sato, M. Suzuki, S. Yasuda, M. Matsumoto, Y. Kunii, K. Mukasa, K. Sugino, K. Ito, S. Nagataki, M. Taniyama, Comparison of efficacy and adverse effects between methimazole 15 mg+inorganic iodine 38 mg/day and methimazole 30 mg/day as initial therapy for Graves’ disease patients with moderate to severe hyperthyroidism. Thyroid 25(1), 43–50 (2015). https://doi.org/10.1089/thy.2014.0084 Historically, Lugol's iodine solution has been widely available and used for a number of health problems with some precautions. [28] Lugol's is sometimes prescribed in a variety of alternative medical treatments. [29] [30] Only since the end of the Cold War has the compound become subject to national regulation in the English-speaking world. [ citation needed] Society and culture [ edit ] Regulation [ edit ] Povidone-iodine is a topical antiseptic agent used for the treatment and prevention of infection in wounds. Povidone-iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis. Why is povidone iodine banned?

Lugol's solution Drug Information, Professional. 1994. Archived from the original on 13 January 2017 . Retrieved 11 January 2017. I've read all of her document now - actually, one of her links to a paper took me to a second, or previous, whatever, slightly different version of that iodine document. I went off and read it not long after I last posted. I appreciate all info, so thankyou for thatThotan et al. report a case of subcutaneous phycomycosis successfully treated with a gradual increase to 15 drops of oral Lugol's iodine solution for 3 months. At 2-year follow up, the patient remained without recurrence and did not suffer any complications of treatment [ 4]. Nevertheless, our case should caution the future use of Lugol's iodine solution due to the inherent risk of iodine toxicity and heart failure.

A.M. Leung, L.E. Braverman, Consequences of excess iodine. Nat Rev Endocrinol 10(3), 136–142 (2014). https://doi.org/10.1038/nrendo.2013.251 Before taking this medication, tell your doctor or pharmacist if you are allergic to iodine or potassium iodide; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

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Health Leads makesLugol'ssolution based on an American formulation: Lugol’s contains iodine (I) and potassium iodide (KI). For a 1000ml (1 quart) amount: 44g (1.5oz) of iodine and 88g (3 oz) of potassium iodide are added to distilled waterand when dissolved this is topped up to make 1000ml of solution. B. Corvilain, J. Van Sande, J.E. Dumont, Inhibition by iodide of iodide binding to proteins: the “Wolff-Chaikoff” effect is caused by inhibition of H2O2 generation. Biochem. Biophys. Res. Commun. 154(3), 1287–1292 (1988) Had got up to x5 drops of 2%, so 12.5mg. Took a further x5 drops at lunchtime today, so 25mg, which equals x4 old Minims of iodine, still salt-loading. Waiting to see how I respond to that. Going purely on instinct and just felt I needed more today.

A.F. Leger, J.P. Massin, M.F. Laurent, M. Vincens, M. Auriol, O.B. Helal, G. Chomette, J.C. Savoie, Iodine-induced thyrotoxicosis: analysis of eighty-five consecutive cases. Eur. J. Clin. Invest. 14(6), 449–455 (1984) P. Pramyothin, A.M. Leung, E.N. Pearce, A.O. Malabanan, L.E. Braverman, Clinical problem-solving. A hidden solution. N. Engl. J. Med. 365(22), 2123–2127 (2011). https://doi.org/10.1056/NEJMcps1008908G.L. Ansaldo, F. Pretolesi, E. Varaldo, C. Meola, M. Minuto, G. Borgonovo, L.E. Derchi, G.C. Torre, Doppler evaluation of intrathyroid arterial resistances during preoperative treatment with Lugol’s iodide solution in patients with diffuse toxic goiter. J. Am. Coll. Surg. 191(6), 607–612 (2000) As a mordant when performing a Gram stain. It is applied for 1 minute after staining with crystal violet, but before ethanol to ensure that gram positive organisms' peptidoglycan remains stained, easily identifying it as a gram positive in microscopy.

The above uses and effects are consequences of the fact that the solution is a source of effectively free elemental iodine, which is readily generated from the equilibrium between elemental iodine molecules and polyiodide ions in the solution. K. Okamura, K. Sato, M. Fujikawa, S. Bandai, H. Ikenoue, T. Kitazono, Remission after potassium iodide therapy in patients with Graves’ hyperthyroidism exhibiting thionamide-associated side effects. J. Clin. Endocrinol. Metab. 99(11), 3995–4002 (2014). https://doi.org/10.1210/jc.2013-4466Prescriptions went from 2 - 6 minims, according to Farrow, right up until c.1950 when antibiotics were first marketed (according to Farrow) and iodine was removed from bread etc and replaced by bromide instead.