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bim•bo

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Fig. 1 (A) TEM images of the UnTHCPSi and UnTHCPSi–HA + nanoparticles. Scale bars are 100 nm. (B) Colloidal stability of UnTHCPSi and UnTHCPSi–HA + after incubation in HEPES buffer (pH 7.4) at room temperature for 4 h. (C) FTIR absorbance spectra of HA (a), HA + (b), UnTHCPSi–HA + (c), and UnTHCPSi (d). The relevant features of each spectrum are highlighted and numbered for clarity (see text for details).

Actualités

This will be a variety of kinks and fetishes, both existing franchises and original characters. Language: English Words: 24,433 Chapters: 5/5 Kudos: 43 Bookmarks: 14 Hits: 21,038 This took place after Kelly asked Trump a question that referenced his television show The Apprentice from season 6 in 2005. Shortly afterwards, Stephen Richter of The Globalist published an opinion piece in which he accused Trump of being a bimbo, noting the original definition of bimbo as "an unintelligent or brutish male". [17] See also [ edit ] M.-A. Shahbazi, P. V. Almeida, E. Mäkilä, A. Correia, M. P. A. Ferreira, M. Kaasalainen, J. Salonen, J. Hirvonen and H. A. Santos, Macromol. Rapid Commun., 2014, 35, 624–629 CrossRef CAS PubMed.

H. A. Santos, L. M. Bimbo, V.-P. Lehto, A. J. Airaksinen, J. Salonen and J. Hirvonen, Curr. Drug Discovery Technol., 2011, 8, 228–249 CrossRef CAS. J.-H. Park, L. Gu, G. Von Maltzahn, E. Ruoslahti, S. N. Bhatia and M. J. Sailor, Nat. Mater., 2009, 8, 331–336 CrossRef CAS PubMed. Recently, hyaluronic acid (HA), a linear glycosaminoglycan consisting of alternating D-glucuronic acid and N-acetyl- D-glucosamine units, has been highlighted as a tumor targeting moiety, relying on its high affinity to CD44 receptor, a type 1 transmembrane glycoprotein up-regulated in a large variety of cancer cells. 43,44 Furthermore, CD44 is known to play a key role in a wide diversity of biological processes, including cell proliferation, differentiation and migration, as well as in angiogenesis, tumor invasion, and metastasis. 45–48 Although involved in diverse physiological and pathological processes, therefore being expressed in non-malignant tissues, 49,50 the CD44 receptor has been shown to be over-expressed in tumor tissues, and a correlation between such occurrence vs. tumorigenesis and metastasis in vivo has already been established. 51,52 In addition to its biological functions, HA presents interesting physicochemical properties, such as high water-solubility, biocompatibility, biodegradability, non-immunogenicity, and chemical structure suitable for further functionalization, which all together make this versatile polymer an attractive biomaterial to be applied concomitantly as a targeting and stabilizing moiety in the development of cancer-targeting drug delivery systems. 53,54

A variety of chemical treatments of the PSi's surface are well established, with emphasis on thermal oxidation (TOPSi) and hydrocarbonization (THCPSi), rendering the PSi materials hydrophilic or hydrophobic properties, respectively. 12,25 Moreover, a variety of active groups, including amine, 21,34,35 carboxylic, and alkyne, 36 can be grafted on the PSi nanoparticles' surface and subsequently functionalized with different bioactive moieties, aiming at the modulation of plasma protein adsorption, 35,37 adaptation to the gastrointestinal environment, 38–40 improvement of tumor-targeting efficiency, 41,42 and/or enhancement of cellular association and internalization. 35,39 C.-F. Wang, E. M. Mäkilä, M. H. Kaasalainen, D. Liu, M. P. Sarparanta, A. J. Airaksinen, J. J. Salonen, J. T. Hirvonen and H. A. Santos, Biomaterials, 2014, 35, 1257–1266 CrossRef CAS PubMed. In the 1940s, bimbo was still being used to refer to both men and women, as in, for example the comic novel Full Moon by P. G. Wodehouse who wrote of "bimbos who went about the place making passes at innocent girls after discarding their wives like old tubes of toothpaste". [8] This form of leveraged buyout (LBO) is used to streamline the transition from one owner to the next with little interruption in business operations. Parents concerned about Miss Bimbo game". Daily Telegraph. London. 2008-03-25. Archived from the original on 2008-03-25 . Retrieved 2008-03-25.