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Comvita Medihoney Antibacterial Wound Gel with Manuka Honey (for Burns, Cuts, Grazes & Ezcema Wounds) - 25g

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Claude Stratford and Alan Bougen established their Paengaroa company in 1974 with a commitment to help people maintain good health. Their original vision of people living healthy lives through a connection to pure natural products still holds firm today. Comvita is one of New Zealand's major producers of high-quality Manuka Honey and honey products. MEDIHONEY wound and burn dressing gel contains a formula of 80% Active Leptospermum Honey (Manuka honey) and 20% natural gelling agents. It’s recommended for the treatment of non-draining to moderately draining wounds, including:

The gel sheet is helpful in treating a wide variety ofmild to moderately exudating wounds. ForDRY woundsthese should be managed withMedihoney Antibacterial Medical Honey. Medihoney Antibacterial Wound Gel 10g is formulated with medical grade manuka honey to help cleans and support the healing process of chronic and acute wounds. Medihoney was applied clinically in a patient with an (a) ankle ulcer infected with methicillin-resistant Staphylococcus aureus. Following application, partial closure was observed at (b) 2 weeks, with complete closure and irradiation of the bacteria observed at (c) 4 weeks. Reproduced with permission from Biglari et al. 38Some drugs may have Authority Required (Streamlined) status which does not require an explicit approval from Medicare, instead the doctor can use the Authority code found in the published Schedule for a given drug/indication. Cutting KF. Honey and contemporary wound care: An overview. Ostomy Wound Manage. 2007;53(11):49–54. Cover the MEDIHONEY gel, paste, or alginate dressing with an absorbent sterile, secondary bandage or a compression garment. Medihoney Gel Sheetis a sterile,non-adherentwound dressing made from Medihoney Antibacterial Honey (80%w/w) and Sodium Alginate for wound care (20%w/w). MEDIHONEY is a brand name wound and burn gel made from 100% Leptospermum (Manuka) honey. Manuka honey is unique in that it has antibacterial and bacterial resistant properties, meaning it prevents bacteria from building a tolerance to its beneficial effects.

MediHoney dressings aids and supports autolytic debridement and a moist wound healing environment in acute and chronic wounds and burns, 5-8 through two key mechanisms – high osmolarity and low pH. The high sugar content of honey facilitates movement of fluid from an area of higher concentration, across a membrane, to an area of lower concentration. Osmotic potential draws fluid through the wound, to the surface, helping to liquefy non-viable tissue. MEDIHONEY looks similar in appearance and texture to traditional store-bought honey, but it’s not a sweetener. Instead, it provides an all-natural way to treat open wounds, preventing gangrene and infection. Often, wounds that have progressed carry a malodorous smell. MEDIHONEY has also been shown to decrease odors that may accompany wounds. MediHoney® dressings are made with a special honey that is derived from the nectar of the Leptospermum plant. This type of honey has unique properties that have been scientifically verified and shown in clinical trials and by other clinical evidence to be effective for the management of wounds and burns. 1-3 MediHoney Paste dressings with 100% Active Leptospermum Honey is ideal for use in hard to dress wounds areas such as tunneled wounds, sinus wounds and wounds with undermining. The MediHoney Paste dressing has the ability to seep down into areas of the wound you may not be able to reach with other dressings.Keep in mind that it’s best that MEDIHONEY be on the skin for 12-24 hours at a time for maximum effectiveness. If you or your loved one is having a hard time keeping the dressing intact, soak a gauze dressing in the MEDIHONEY (or use the MEDIHONEY square dressing) and apply it directly on the wound, then top with an abdominal pad dressing. When using MEDIHONEY will I need any extra supplies? The hygroscopic properties of honey mentioned previously derive from the high sugar content and, subsequently, high osmolarity of honey. When incorporated into a wound dressing, the osmotic effect of the sugar in honey results in water being drawn out of the wound bed. When combined with a sufficient circulation of blood beneath the wound to replace the lost fluid, this osmotic effect results in an outflow of lymph, and clearance of bacteria from the wound that may mimic the effects of negative pressure wound therapy. 12 However, honey osmolarity varies greatly and consequently, as do the antimicrobial benefits, where an increased water content decreases these effects. 2 Serious wounds, such as some of those listed above, should be managed under professional medical supervision. The inhibition zone of (a, b) Pseudomonas aeruginosa and (c, d) Staphylococcus aureus by chitosan–poly(vinyl alcohol)–gelatin–thyme honey hydrogel films. Note that the film on the left side of the petri dish in (a, b) as well as the right side of (c, d) are films composed of 0.03, 0.04, 0.03, and 0.03g/mL of chitosan, PVA, gelatin, and honey, respectively. The right film in (a, b) and the top film in (c, d) is composed of 0.05, 0.02, 0.03, and 0.03g/mL. Finally, the left film in (c, d) is composed of 0.05, 0.04, 0.03, and 0.03g/mL of chitosan, PVA, gelatin, and honey, respectively. Reprinted with permission from Lahooti et al. 59 Regulski, M. A novel wound care dressing for chronic leg ulcerations. Podiatry Management, 2008. November/December: p. 235-246.

Prescriptions must be written on an Authority Prescription Form, and the approval number must be noted on the prescription. Pharmacists cannot dispense the item as a pharmaceutical benefit unless it has been approved by Medicare Australia (indicated by the presence of the approval number). Yes. Due to the osmotic potential there can be an increase in exudate and wound fluid to the wound area. Applying a skin protectant to the surrounding skin will help to prepare and protect the area from excess moisture and fluid.Leg ulcers, pressure ulcers, first- and second-degree burns, diabetic foot ulcers, surgical wounds, and traumatic wounds 88 This gels unique properties helps to provide broad spectrum antimicrobial activity, creating an antibacterial barrier, and creates a favorable environment to support wound healing. Also helps reduce malodours. Bateman S, Graham T (2007) The Use of MediHoney® Wound Gel on surgical wounds post-CABG. WOUNDS UK; Vol 3(3). 76 – 83. Recent Advances: The past and present clinical use of honey is noted, focusing specifically on burns and ulcers, as these are the most common applications of the natural agent. While honey is often used without modification clinically, there are also commercially available products ranging from dressings to gels, which are discussed. Cryogel fabrication is achieved through the freezing of a polymer solution immediately after cross-linking, resulting in ice crystals surrounded by the formation of gel-like matrices in this frozen environment. When thawed, the ice crystals melt out, leaving a mechanically durable, spongy, and a macroporous structure with interconnected pores. 45, 67 Although cryogels as tissue engineering templates have become increasingly popular in recent years, the incorporation of honey is restricted to a few articles. As of this article, the current materials that have been used are silk fibrin, 8, 67 gelatin, 8, 68 PVA/chitosan, 61 and PVP/PVA/Keratin/PEG. 69 Note that a hybrid chitosan–gelatin–honey-incorporated cryogel showed promising in vivo wound healing; however, the scaffold contained an array of active ingredients, making it impossible to discern the effects of honey alone. 68

Robson, V., Dodd, S and Thomas, S. Standardized antibacterial honey (MediHoney®) with standard therapy in wound care: randomized clinical trial. Journal of Advanced Nursing, 2009: p. 565-575. Thoroughly clean the wound with a saline solution. (Here’s a recipe from IntermountainHealthcare). Then, if necessary, apply a barrier cream around the edges of the wound. Barrier cream prevents skin breakdown and infection. Second, Manuka honey contains a much higher concentration of methylglyoxal (MGO) than regular honey. MGO is an organic compound known for its antibacterial and antiviral properties.MEDIHONEY is different from regular honey in several ways. For one, it’s only produced by bees that pollinate the Manuka flower, a species of tea tree native to New Zealand. Kamaratos AV, Tzirogiannis KN, Iraklianou SA, Panoutsopoulos GI, Kanellos IE, Melidonis AI. Manuka honey-impregnated dressings in the treatment of neuropathic diabetic foot ulcers. Int Wound J. 2012 ; 9: 1-7. Note that the honey led to the formation of healthy granulation tissue and expediated healing, with 33 of the patients experiencing wound healing within 10 days. Modified with permission from Subrahmanyam. 27 Scanning electron microscopy images of electrospun PVA with (a) 0%, (b) 20%, and (c) 40% Iran–Tabriz honey. Note that with increasing wt% of honey, there appeared to be beading within the fibers, as shown in (c). Reproduced with permission from Maleki et al. 46 PVA, poly(vinyl alcohol). Authority to prescribe an Authority medicine is granted for specific indications and/or for certain patient circumstances. Authority may be obtained by telephone to Medicare Australia (known as "phone approval") or in writing from an authorised delegate of the Minister for Health.

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