The last thing I see is the empty eyes of my mate before I lose consciousness. The last coherent thought I have is knowing that I’m alone. India is on the wrong side of history,’ declared President Bill Clinton post New Delhi’s nuclear tests in 1998 and came down with an array of sanctions. Cut to the present, India is no longer the enemy for the US. In an age dominated not just by China’s rise but by its undoubted political and economic muscle power, India has become the fashionable new ally in Washington.

I’m blinded. All I could hear was the ringing in my ears. The wolf’s bane grenade had gone off. I squint as the fog cleared. Everything was moving in slow-mo as I tried to find him. Tried to smell him. She saw the hardness once more return to his features, his fingers gripping her tighter. “You are exactly who I think you are Sara. Did it give you pleasure to fire me all those years ago, when I told you I was innocent - to accuse me of being a thief? Did it make you feel good? Because now it is my turn and believe me, I am going to enjoy this” With that he hauled her hard up against himself, his mouth taking hers in a punishing kiss, her whimper lost as she tried in vain to push him away, his arms moving around her waist, holding her tightly to him. Ashley J. Tellis, the Tata Chair for Strategic Affairs at the Carnegie Endowment for International Peace, and former senior adviser to the US State DepartmentI find you attractive Tia...so tell me...Knowing that I will never expect anything more from you, and in fact will insist that once the month contract is up, that we never see each other again...are you attracted enough to me to explore your own boundaries?”

The phone call that came from April as she entered her apartment later that night was far from unexpected. Once more she felt the jolt of hurt at his words, but kept her features impassive, not wanting to give him the satisfaction of seeing her upset, her mouth clenched tightly shut, her mind struggling to accept what was going on. For the first time she realised that deep down she felt that he would not really force her into his bed - that he was only trying to humiliate her. The man she knew six years ago was fair and held in high esteem by the other contractors and employees. Did he not realise he had humiliated her enough? In doing so, the explainer has attempted to shed some light on why governments, regulatory authorities, pharmaceutical companies and others take the decisions they do on the pricing and funding of new medicines: for example, why pharmaceutical companies often set high prices for new drugs, why governments allow them to do this, and why NICE recommends some expensive new drugs for the NHS while rejecting others. It has also discussed why authorities have sometimes found themselves reaching contentious decisions, such as NICE’s recommendations on Visudyne, and why the authorities have adapted their decision-making for particular groups. She can’t be called badass for nothing. But everything she planned out got destroyed when she met the CEO, who happens to be more badass than her! Everything she does is always flawed and she always being lost in the end! This is her first time being defeated by the arrogant CEO! If Millijay is the badass secretary, then Farris is the living devil CEO! Companies can typically set high prices for a patented new drug on release, particularly if there are no alternative treatments for the condition. If other companies launch effective new treatments while a drug is in patent, the incumbent may then be forced to reduce prices if it wants to continue selling its drug in large volumes. However, it is only when the patent expires that companies can start manufacturing and selling generic versions of the drug (a medicine with the same active pharmaceutical ingredient as the originator drug) or a biosimilar version for more complex drugs (a medicine that doesn’t have any clinically meaningful differences from the originator drug). When generics or biosimilars enter the market, prices go down and the originator’s profits typically drop rapidly.

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Now that is a good best friend.” Paul snuggled her closer, and she was thankful for the dark, because she couldn’t hide how much she felt for him in that moment. Patents are a particularly powerful mechanism for protecting prices and profitability in medicines. This is because new medicines are easy to define and patent (as a chemical entity has a specific formula that can be patented). It is also because both public health care and private health insurance look to insulate the patient and doctor from the cost of paying for health care at the point of use. This means patients and doctors are not put off by high prices because they do not pay them directly. Governments and insurers meanwhile want to give as many people access as they can, while keeping control of spending. Seema Sirohi has used her thirty-year experience in Washington, and deep knowledge of India and the US to write an accurate, accessible and timely account of the relationship. Mindful of pitfalls, past and future, this is not purely an optimistic tome, though it does show the good that diplomacy and political will can achieve. Friends with Benefits is well worth reading to make sense of an increasingly important relationship in a constantly changing and troubled world.’ Really?” Laura was surprised to hear that about the happy, confident woman she had met that afternoon. Cut to the present, and the geopolitical arena is dramatically different. The US no longer sees India as an adversary but as an indispensable partner. China’s determined rise has significantly changed Washington’s strategic calculus. Today the US is busy trying to retain its pre-eminent position in the world by creating new friendships and alliances.

I roll my eyes, “Morning Gabe.” Tactfulness wasn’t his strong suit, but at least I could rely on him to tell me the truth. After a laughing clink of their glasses, a cosmo for Tina, a gin and tonic for April, and a margarita on ice minus the salt for Laura, they let out a collective sigh of happiness. Until Tina started up on a recurring argument. “Now that you are finding a new job, it is on to finding a new man, girlfriend. This dry spell of yours is turning into the Sahara.” The very first time she meets him she knows he’s what she wants, what she needs. It will be mutually beneficial for the both of them. Hot, satisfying sex on tap for the both of them. That’s all she wants, all she’s looking for, right? Falling in love isn’t on the agenda, for either of them. Kelly—she said you were an amazing lover and she couldn’t get enough of you. She said that just thinking of you made her pussy wet. I want to know what that feels like.”

Flinching, she bit her tongue and then exhaled. “When I moved in with Jeff, he said it was because it made sense. It was supposed to be for us to save for the wedding. It was the smart thing to do. Three years later and a week before a wedding ceremony that was going to be done downstairs in the freaking basement just so he could shut me up, I found him in bed with someone else. I found out then he only asked me to marry him because he knew I wouldn’t have sex with him until he made a commitment. Please spare me the details, Gabe. I do NOT want to hear where, how, or what positions you had her in. I’ll take your word for it. Now please shut uuup”, I groan. Gabe is one of my closest friends but I swear he’s a man whore. She was waiting, still waiting for him to say the words she needed so badly, but he was just staring at her. Setting the glass down with a clink, she looked down at her hands, now clasped together, and prayed her voice wouldn’t tremble. “I do want to be with you and I like being here with you, but I need some time to think about this.” Governments protect companies’ investment incentives by granting patents, giving companies that develop new drugs the exclusive right to make and sell their new drug, and preventing other companies from selling an identical product. Patents typically last for 20 years from the date of filing. In doing so, they generally give the firm the ability to set above-competitive prices until the patent expires. No. If you can’t come then neither can I. You are too sore. This is the price I have to pay for not taking care of you.”

Shyam Saran, former foreign secretary, Government of India, and former special envoy for the Prime Minister for nuclear issues and climate change The same could be said about you. I’m still finding it hard to believe with all of that you managed to have two boyfriends, let alone one.” It just makes sense. I want you here all the time and you want to be too. So why don’t you just move in?” If the research request is approved, the company first conducts phase 1 clinical trials to determine that the drug is safe in small doses in healthy volunteers. If the drug proves to be safe for humans, the company launches phase 2 clinical trials to gather information on dosage, side effects and efficacy for particular conditions. These are typically smaller-scale randomised controlled trials where people are selected at random to take the drug or an alternative treatment or placebo. Since its establishment, NICE has recognised the case for considering a broader range of ethical perspectives in its decision-making. As it explains in its note on decision-making principles, ‘NICE believes that overall population needs are paramount in determining the fair allocation of resources. But it also recognises that in some circumstances, in the interests of fairness, the needs of particular groups may override those of the broader population.’

Friends with Benefits is a detailed, punchy and richly reported account of the last several decades of Indo-US relations. Seema Sirohi, a long-time observer of the relationship, has written an entertaining book that balances incisive analysis with valuable original reportage. A fascinating read.’ There have been several books on India–US relations in recent years, but what makes Seema Sirohi’s Friends with Benefits unique is the perspective she offers as an accomplished journalist on how the two vibrant democracies have journeyed from estrangement to engagement. Her insights, drawn from an extended involvement with the subject, are both sharp and incisive.’