Gupta RS, Patel S, Saini N, Chen S. Robust demarcation of 17 distinct Bacillus species clades, proposed as novel Bacillaceae genera, by phylogenomics and comparative genomic analyses: description of Robertmurraya kyonggiensis sp. nov. and proposal for an emended genus Bacillus limiting it only to the members of the Subtilis and Cereus clades of species. Int J Syst Evol Microbiol. 2020;70(11):5753-5798. View abstract. Follow the recommended dosage: Adhere to the dosage instructions on the product label or as directed by a healthcare professional to maximize Lactospore's benefits. And by the way, if you go to Pub Med and you type in Saccharomyces Boulardii, there’s a ton of research on also diarrhea. Reid G, Bruce AW, Cook RL, et al. Effect on urogenital flora of antibiotic therapy for urinary tract infection. Scand J Infect Dis 1990;22:43-7. View abstract. Some studies suggest that Lactospore may help reduce total cholesterol and low-density lipoprotein (LDL) cholesterol levels, potentially contributing to improved cardiovascular health (8). IV. How to Incorporate Lactospore into Your Routine

Urgesi R, Casale C, Pistelli R, et al. A randomized double-blind placebo-controlled trial on efficacy and safety of association of simethicone and Bacillus coagulans (Colinox) in patients with irritable bowel syndrome. Eur Rev Med Pharmacol Sci 2014;18(9):1344-53. View abstract. So I had been using them in experimenting with different probiotics over decades and decades, and I learned so much about what they do, their role, why they’re important, how they work, how they don’t work, which ones are good, which ones are bad. And it’s a little bit overwhelming out there for people to figure out what do I take and which one do I take and if it’s cold or in the fridge, can it be on the shelf? What do I take for this condition, for that condition? And they’re varied because there’s literally thousands of different microbes and they all have different roles. They all do different things and they all have different benefits. So it’s really about customizing and personalizing, but there are some basic ones that have really important functions, and we’re going to talk about that. Absolutely. And there’s different bacteria for different things. For example for babies, often there’s a particular bacteria called Bifidobacterium infantis that’s really important for immune development, and it’s absent in most babies because the mothers have had an antibiotic some time in their life and wiped that out, or they’re born by C-section. And the 25% of calories that’s in breast milk that’s not digestible by babies is there to feed this particular bacteria and others called bifidobacterium infantis. And if you have low levels, it’s a big problem. So you can actually give the baby probiotics when they’re born in the first 100 days to help them colonize with bifidobacterium infantis and avoid the autoimmunity, the allergy, the eczema, and all these other downstream things that are going to happen if you don’t have this important bacteria. So that’s just another example of how different strains do different things.Lactospore is a powerful probiotic strain with significant potential to improve gut health and overall wellness. Its ability to survive harsh conditions and provide a range of benefits, from enhancing gut barrier function to supporting immune and mental health, makes it A4: Lactospore can be incorporated into one's routine via dietary supplements such as capsules, powders, and functional foods. It's essential to choose a reputable product from a trustworthy brand, follow the recommended dosage, and maintain a balanced lifestyle to maximize the benefits of Lactospore. Q5: Is it necessary to consult with a healthcare professional before incorporating Lactospore into your routine? FAO/WHO. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria, Report of a Joint FAO/WHO expert consultation on evaluation of health and nutritional properties of probiotics in food including powder milk with live Lactic acid bacteria. Córdoba, Argentina: 2001. Available at: ftp://ftp.fao.org/docrep/fao/009/a0512e/a0512e00.pdf. Accessed 24 February 2016.AQ7

So Mark, take us a little bit deeper really on the topic of why do we need probiotics and how can they be beneficial? Like what are actually the things that they make a difference on when it comes to our health? So the beautiful thing about fermented foods is that they can help reduce this process by normalizing gut function, by optimizing the gut in different ways, through optimizing healthy bacteria, reducing the bad bugs, which then reduces the leakiness of the gut, which then further limits the inflammatory cascade that results as a result of a leaky gut. So it’s really kind of a beautiful story about how your microbiome plays a role in your immune system, plays a role in your weight, and how that all connects to eating the right foods and not eating the wrong foods. Lactospore has been shown to improve gut barrier function by increasing the production of tight junction proteins, which help maintain the integrity of the intestinal lining. This reduces the risk of toxins and pathogens entering the bloodstream and supports overall gut health (3). C. Anti-Inflammatory Properties Thirty six newly diagnosed diarrhea predominant IBS patients were enrolled in three clinical centres. Along with standard care of treatment, 18 patients in group one received placebo while in group two 18 patients received B. coagulans MTCC 5856 tablet containing 2 × 10 9 cfu/day as active for 90 days. Clinical symptoms of IBS were considered as primary end point measures and were evaluated through questionnaires. The visual analog scale (VAS) was used for abdominal pain. Physician’s global assessment and IBS quality of life were considered as secondary efficacy measures and were monitored through questionnaires. ResultsNo, absolutely. There’s ton of great companies that are doing stuff in the space. And I think through education and digging in a little bit and asking the companies how they approach it, that’s a big part of the process. Talk a little bit more about LactoSpore, which is the probiotic that you put in your formula. Probiotics for antibiotic-associated diarrhea. Pharmacist's Letter / Prescriber's Letter 2000;16(1):160103. And can you still take a probiotic for instance and get the benefits because it’s not exactly like there’s a clear test to say you have to go and do the weeding first, unless sometimes you’re working with a functional medicine doctor they can help you interpret it.

So a couple last things on the topics of probiotics. Almost everybody in the world has taken an antibiotic at some point in time, and people are always curious about that. On one extreme, there’s this deep, deep, deep fear that, “Oh my gosh, I’ve heard so much about the gut microbiome from functional medicine doctors and experts like yourself and I’m just worried to take an antibiotic ever.” And on the other side it’s like, “The data’s way overblown. We’re fine, antibiotics, the body’s resilient.” Tell us where you lie on that spectrum of things. Kimmel, M., Keller, D., Farmer, S., & Warrino, D. E. (2010). A controlled clinical trial to evaluate the effect of GanedenBC30 on immunological markers. Methods and Findings in Experimental and Clinical Pharmacology, 32(2), 129-132. Is so key. So Mark, when it comes to shopping for probiotics, what are some of the things that people can be looking for when choosing the right probiotic?a) a substance including a microorganism that does not have a history of safe use as a food. 2.Product Development

They’re resistant to antibiotics (wow), and the digestive enzymes effectively help break down nutrients into amino acids, making them more readily absorbed by the body. My Experience with LactoSpore ® But yes, on the topic of what we’ve been up to with our product Gut Food, and go to gutfood.com and learn a little bit more about it and join the wait list, we thought a deep dive into the topic of probiotics would be a fantastic fit for not just chatting about our product, but answering people’s questions. So Mark, I’m going to take you big picture and just say why do we need probiotics in the first place? And when was the first time that you encountered in your journey and even had heard the term probiotic? Maity C, Gupta AK. A prospective, interventional, randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and safety of Bacillus coagulans LBSC in the treatment of acute diarrhea with abdominal discomfort. Eur J Clin Pharmacol. 2019;75(1):21-31. View abstract. All right Mark, well we talked about a bunch of companies that you love and use and trust on a regular basis. We’ll have a link to those. We’re all about lifting everybody up and highlighting and putting the spotlight on companies that you love and that you use in your clinic and they use at the Cleveland Clinic as well too in some cases. So we’ll have a link to those in Show Notes, as well as some of the studies that we mentioned, we’ll put those in the show notes as well. And with that, I think we can go ahead and conclude today’s episode. Well, thanks Dhru. It’s been a fun class. I think we really always have more to learn about the microbiome, about probiotics, about how to fix the gut, and the exciting part about this era is we’re learning more every day and I’m learning more every day. And I’ve been doing this for 30 years, so it’s pretty exciting. So if you like what you heard on this podcast and you want to learn more about our new multivitamin for your gut called Gut Food, just visit gutfood.com to sign up for the wait list and be sure to share this podcast with your friends and family and we’ll see you next week on The Doctor’s Farmacy.

LactoSpore®’s premium preparation of Bacillus coagulans in a convenient tablet form, providing an incredible 600 million spores in a single tabet serving. If modern foods contained all the goodness they once did, and if we lived like humans naturally once did, we wouldn’t need probiotics. But the thing is, we don’t. Why LactoSpore® ? In a world full of pollution, processed foods, sugar, pharmaceuticals, too much time indoors and not enough access to high quality air or high nutrient foods, it can be a struggle for the body to work as optimally as it could. Add to that a lifestyle filled with stress-inducing deadlines, work schedules, relationship issues and financial instability. It’s no wonder our gut health definitely isn’t as vibrant and healthy as it could be. And when you look at some of the data, and we have really good data on the product that’s in our formula called LactoSpore. LactoSpore is a spore based probiotic, and when they did clinical trials, a pilot study but it was a randomized control trial, they found a 42% reduction in bloating and irritable bowel, a 47% reduction in vomiting, a 43% reduction in diarrhea, and a 68% reduction in pain. And even more remarkably, they looked at what happened to the brain because how is the gut and the brain connected? Well, they are very connected through the gut brain connection. And depression went down 57%. Sleep got better 58%, dementia symptoms went down 26%, quality of life went up 47%, along with GI discomfort going down by 62%.