Guo J, Chen H, Zhang X, et al. The effect of berberine on metabolic profiles in type 2 diabetic patients: a systematic review and meta-analysis of randomized controlled trials. Oxid Med Cell Longev 2021;2021:2074610. View abstract. Ghosh AK, Bhattacharyya FK, and Ghosh DK. Leishmania donovani: amastigote inhibition and mode of action of berberine. Experimental Parasitology 1985;60:404-413.

Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. View abstract. Pentobarbital is a medication that can cause sleepiness. Berberine might also cause sleepiness and drowsiness. Taking berberine with pentobarbital might cause too much sleepiness.

Dong H, Zhao Y, Zhao L, Lu F. The effects of berberine on blood lipids: a systemic review and meta-analysis of randomized controlled trials. Planta Med 2013;79(6):437-46. View abstract. Canker sores. Applying a gel containing berberine can reduce pain, redness, oozing, and the size of canker sores. A: Berberine primarily acts on your body’s metabolic environment, helping to prevent the stresses of a poor diet and the stresses of being overweight or obese from causing increases in your blood lipids and blood cholesterol.

Marin-Neto, J. A., Maciel, B. C., Secches, A. L., and Gallo, Junior L. Cardiovascular effects of berberine in patients with severe congestive heart failure. Clin.Cardiol. 1988;11(4):253-260. View abstract. Wang, Y., Jia, X., Ghanam, K., Beaurepaire, C., Zidichouski, J., and Miller, L. Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters. Atherosclerosis 2010;209(1):111-117. View abstract. Berberine has been used in a few scientific studies to reduce blood lipids and blood pressure, which can help decrease your risk of heart disease. To follow the protocols from these studies as closely as possible, go for a pure and concentrated berberine supplement like Thorne Research Berberine, which boasts 500 mg of 85% berberine extract. Rabbani G. Mechanism and treatment of diarrhoea due to Vibrio cholerae and Escherichia coli: roles of drugs and prostaglandins. Danish Medical Bulletin 1996;43:173-185. Children: It's likely unsafe to give berberine to newborns. It can cause kernicterus, a rare type of brain damage that can occur in newborns who have severe jaundice. There isn't enough reliable information to know if berberine is safe in older children.Zhang, M. F. and Shen, Y. Q. [Antidiarrheal and anti-inflammatory effects of berberine]. Zhongguo Yao Li Xue.Bao. 1989;10(2):174-176. View abstract. Naturebell provides a solid berberine supplement with a high dose of 600 mg per capsule, which is nice for more aggressive supplementation routines shooting for 1200 mg per day in two separate doses. Aside from this, the purity and supplement design is good but not the absolute best . 8. Dr. Whitaker’s Clinical Grade Berberine Toniq delivers a highly purified version of berberine extract at a solid 500 mg dosage. It’s a great go-to option if you want a simple and pure berberine supplement at a typical dosage, though the capsule has a few more binders and fillers than we’d like to see. 10. Sunergetic Berberine Some research suggests that berberine works for weight loss, but not as well as some of the more high-powered compounds for weight loss like green tea extract .

Sun D, Abraham SN, Beachey EH. Influence of berberine sulfate on synthesis and expression of Pap fimbrial adhesin in uropathogenic Escherichia coli. Antimicrob Agents Chemother 1988;32:1274-7. View abstract. Research shows that Berberine supports healthy blood sugar levels, that it maintains blood sugar levels before and after meals, and even supports healthy triglyceride levels, total and LDL cholesterol levels, and healthy blood pressure. Jantova, S., Cipak, L., Cernakova, M., and Kost'alova, D. Effect of berberine on proliferation, cell cycle and apoptosis in HeLa and L1210 cells. J Pharm Pharmacol 2003;55(8):1143-1149. View abstract. Fukuda K, Hibiya Y, Mutoh M, et al. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J Ethnopharmacol 1999;66:227-33. View abstract. Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. View abstract.

Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102. View abstract. Huang XS, Yang GF, Pan YC. Effect of berberin hydrochloride on blood concentration of cyclosporine A in cardiac transplanted patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28:702-4. View abstract. Dutta NK and Panse MV. Usefulness of berberine (an alkaloid from Berberis aristata) in the treatment of cholera (experimental). Indian J Med Res 1962;50(5):732-736.

Women benefit from the highly bioavailable delivery of berberine in this supplement, with easier absorption thanks to the MCT oil used to dissolve the active compounds in berberine. The 500 mg dosage is a good fit for many women as well . Hong, Y., Hui, S. S., Chan, B. T., and Hou, J. Effect of berberine on catecholamine levels in rats with experimental cardiac hypertrophy. Life Sci. 4-18-2003;72(22):2499-2507. View abstract. Ming J, Yu X, Xu X, et al. Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study. Genome Med 2021;13(1):125. View abstract. Unlike many other companies, Integrative Therapeutics is doing something innovative with its berberine supplement. It uses three different plant species as sources of berberine, and one of them is combined with several of the other related compounds in the plant that are bioactive.Current research conducted both in vitro and in vivo points to the potential efficacy of berberine in helping to favourably regulate glucose and lipid metabolism in people with blood sugar dysregulation. Berberine has been shown to enhance glucose consumption in hepatocytes and adipocytes, even in the absence of insulin, and may help to enhance glucose metabolism via stimulation of glycolysis, the metabolic pathway which converts glucose into pyruvate which also is associated with inhibiting glucose oxidation in mitochondria.