Madvillainy marked Dumile’s first entry in the Billboard Top 200, though an oft-promised sequel never materialised, Madlib suggesting the ball was firmly in Doom’s court. Dumile instead cut further collaborative albums with the likes of Danger Mouse, Jneiro Janel, Bishop Nehru and Czarface. There was also a final solo album, 2009’s Born Like This, which drew inspiration from Charles Bukowski and teamed Doom with the likes of the Wu Tang’s Raekwon and Ghostface Killah. On 23 October 2020, Thompson had breathing problems after taking new medication and went to the A&E department at St James’s hospital where he was given adrenaline, steroids and oxygen. In 2004, under the name MF DOOM, he released MM.. FOOD—an anagram of M.F. DOOM. His next solo album, Born Like This, mostly fell under the radar, but is still beloved by fans. It spawned multiple classic songs, such as “Gazzillion Ear,” “Ballskin, ” and the lyrically-inclined “That’s That.” DOOM then received critical acclaim for his 2004 collaboration with producer Madlib, titled Madvillainy. With a 93/100 score on Metacritic and praise from hip-hop legends, Madvillainy is known as one of the best rap albums of all time. DOOM told an interviewer why he likes collaborations:

The musician, who had several medical conditions including kidney failure, type 2 diabetes, heart failure and hepatitis B, underwent kidney dialysis in Leeds in July 2020. She said that when Thompson suggested the swelling in his throat, tongue and lips were getting worse, this should have triggered a request for a review at the hospital, although it was not possible to say whether his collapse could have been avoided. What I usually do when I’m producing a record, I’ll come up with the beat first, and then the beat will inspire the lyrics, you know what I’m sayin'? […] I heard the loop first, cut the loop, put the drums to it, polish it up with the 808s, but I don’t really over-do it too much. I like to try to keep it as close to the original as possible. Leave something for the imagination, but enough to get the translation across. Then just write to it, keep it simple. Using his JJ DOOM collaboration album as an example, DOOM explained the process behind his iconic, obscure TV dialogue samples and skits:

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The collaboration is much more than apparel; it’s a cultural moment. With Supreme's commitment to quality and MF DOOM's timeless influence on music, the collection promises to be a tangible link to a legend who left us far too soon. The drop is highly anticipated as a fashion statement and a salute to one of rap’s most virtuoso authors and mysterious figures. I don’t watch TV but I do that all day. I be cleaning the house and playing some obscure, weird shit. And it’ll be fun stuff, I bump into some interesting things. The London-born rapper, one of hip-hop’s most distinctive MCs and producers, who was part of the American hip-hop duo Madvillain alongside Madlib, died at St James’s hospital in Leeds. Also an established producer, DOOM released multiple compilation albums of his beats, such as the Special Herbs series. He spoke about his producing/songwriting process in the same interview: The idea of having different characters is really to get the storyline across. The idea of having one different character all the time, to me, makes – to me – the story boring… So the more, the better with me. This way I could come from one point of view, another point of view. They might even disagree on certain things. I think a lot of times, especially in hip-hop, artists get pigeonholed into being, ‘You’re the guy.’ It’s kind of limiting in a way. I look at it like I’m the writer. Same way with the skits. Have the record tell the story

I love collaborating, I’m a team player. I love it when I’m working with other artists and see how they get down and exchanging ideas, it’s fun. His condition appeared to improve but then suddenly deteriorated and he collapsed. Thompson, who had six children, was put on a ventilator and died on 31 October. He’s more like the old-school, OG, old-timer villain. He’s the typical villain you’d have in any story. A lot of people misunderstand him, but he’s always looked at as the bad guy, but really he’s got a heart of gold. He’s for the children. He’s like a Robin Hood kind of character. Afterwards, the Leeds teaching hospitals NHS trust issued an apology. Dr Hamish McLure, its chief medical officer, said: “I would like to offer our sincere condolences to Daniel’s family, friends and fans at this difficult time. I apologise that the care he received was not to the standard we would expect. The inquest heard he had registered with a new GP in the city and doctors had been unable to access his previous medical notes because of concerns about data protection.But the collection isn’t merely a rehashing of old designs; it’s a finely tuned fusion of streetwear and rap culture. The beanie, for instance, showcases a co-branded Supreme and MF DOOM logo, encapsulating the synergy between the rapper's indelible legacy and Supreme's streetwear aesthetic. The assistant coroner Janine Wolstenholme said a care plan drawn up in hospital was not sufficiently detailed and that doctors were given a “false reassurance” about the musician’s condition when his health appeared to improve.

The upcoming Supreme collection includes a hooded sweatshirt, a t-shirt, and a beanie, all available in multiple colorways. Both the hoodie and the t-shirt boast MF DOOM's iconic metal mask design, with additional elements like a machete and graffiti-style logos. On the reverse, the pieces feature a tribute that mirrors the graffiti logo first seen on the cover of DOOM's debut solo album, "Operation: Doomsday," along with a heartfelt letter inspired by the album's original liner notes. She apologised to Thompson’s wife, Jasmine, who followed the inquest via video link from the US, for the time it had taken to bring the matter to the court. The coroner said the trust accepted that doctors had not sought “specialist input” about the patient’s condition from an immunology expert. In a tribute to the hip-hop legend MF DOOM, streetwear titan Supreme is gearing up to release a specially-curated collection. This collaboration with the late rapper's estate forms part of the brand's Fall/Winter 2023 Week 3 drop and is set to release on September 7. For those familiar with the unparalleled creativity and mystique that defined MF DOOM’s life and career, the Supreme x MF DOOM Collection serves as both an homage and a collector's must-have.

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Wolstenholme concluded the inquest with a narrative verdict that touched on a number of issues highlighted by Thompson’s wife and her legal team. Yeah and for the record I didn’t get the idea from [Doctor Doom]… [laughs]. I been Doom ever since I was born, my momma call me Doom so…