a b Kimball SR, Jefferson LS (January 2006). "Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis". The Journal of Nutrition. 136 (1 Suppl): 227S–31S. doi: 10.1093/jn/136.1.227S. PMID 16365087. We've outfitted our family with a variety of Xtend products, each geared to assist you in your health and fitness journey. No matter what your goal is, whether it be losing weight, building muscle, or performing better, let us be the match maker. Are you wanting zero artificials, a boost of energy or something you can take with you On The Go? We're still your team! Fontana L, Cummings NE, Arriola Apelo SI, Neuman JC, Kasza I, Schmidt BA, etal. (July 2016). "Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health". Cell Reports. 16 (2): 520–530. doi: 10.1016/j.celrep.2016.05.092. PMC 4947548. PMID 27346343. The addition of glutamine was one of the things that attracted to try Xtend. I had taken regular glutamine powder before and it always had a tremendous impact on my recovery.

When you eat a meal that includes at least 3 grams of leucine and at least 30 grams of protein, muscle protein synthesis is spiked momentarily. About two hours after the meal, protein synthesis will have dropped, but the amino acids from the meal are still in the bloodstream. At this time, if you provide another 3 grams of leucine (as well as the other two BCAAs), it may create a second spike in muscle protein synthesis from that same meal.XTEND also contains an electrolyte blend, each serving providing 220 milligrams of sodium and 170 milligrams of potassium. Additionally, each serving provides a hefty portion of vitamin B6, which has been linked 3 to muscle growth and repair. XTEND BCAA is designed with a 2:1:1 ratio of the essential amino acids L-leucine, L-isoleucine, and L-valine a b Choi S, Disilvio B, Fernstrom MH, Fernstrom JD (November 2013). "Oral branched-chain amino acid supplements that reduce brain serotonin during exercise in rats also lower brain catecholamines". Amino Acids. 45 (5): 1133–42. doi: 10.1007/s00726-013-1566-1. PMID 23904096. S2CID 1957988. If Stevia does not cause you any stomach issues, Transparent Labs BCAA Glutamine is a well-formulated supplement worth considering.

Sustainable muscle energy means you don’t get fatigued as fast. My workouts tend to be on the side of higher volume, so being able to last longer is important. If you’re looking for a boost of electrolytes and some high-quality BCAAs, Xtend may be a good choice for you. It contains artificial sweeteners, which do a great job at masking any bitter taste but may be a dealbreaker for some. Key ingredients include L-Leucine, L-Glutamine, L-Isoleucine, L-Valine, electrolyte blend, and citrulline malate. When it comes to fat-burning, BCAAs and leucine intake could help with weight loss. "Supplementation of the BCAA leucine, especially in combination with glutamine, has been shown to help overweight subjects on a hypocaloric diet," says Mitchell. "Helping to reduce excess fat, and helping to normalise visceral fat, which is a marker of metabolic problems."

Warnings

XTEND Perfect 10 Amino is a scientifically formulated essential amino acid (EAA) blend perfectly engineered to support muscle recovery and growth. Our blend of EAAs, including the three critical BCAAs, has been calibrated to mimic the EAA composition found in human skeletal muscle tissue. In other words, the ratio of EAAs in XTEND Perfect 10 Amino is designed to match what's in your muscle. L-glutamine, malate, citric acid, sucralose, malic acid, artificial sweeteners and flavors, food dye #40 To answer this question, several groups have combined data from genome‐wide association studies (GWAS) with BCAA and insulin levels. One meta‐analysis found several single nucleotide polymorphisms (SNPs) in genomic regions of BCAA catabolism and connected these SNPs to elevated BCAAs and insulin resistance (Lotta et al., 2016). Two similar studies presented opposing results, postulating that though BCAAs are elevated in type II diabetes, this is caused by genetic risk for insulin resistance (Mahendran et al., 2017; Wang et al., 2017). Recent research in this field has concentrated on what increases circulating BCAAs, how this interacts with dysregulated metabolic states such as insulin resistance, and what methods are most effective at restoring BCAA levels.

The field of BCAA metabolism has been advanced with the use of large, multi‐omics data analyses and metabolic tracing experiments that can determine the tissue‐specific use of AAs. The new model proposed by Neinast et al. is certainly a more comprehensive assessment of whole‐body BCAA catabolism (Neinast et al., 2019); however, there are still a few outstanding questions. Although this updated model seems to agree with previous literature, it only accounts for approximately 50% of whole‐body BCAA disposal; for example, one major metabolic organ not evaluated was the gut, home to intestinal microbiota that can produce BCAAs and other essential amino acids (Lynch & Pedersen, 2016; Pedersen et al., 2016; Ridaura et al., 2013). Furthermore, there are discrepancies in the literature regarding the expression and modification of BCAA catabolic enzymes, and how this relates to tissue‐specific BCAA oxidation. It will be interesting to see how models of BCAA catabolism evolve, especially as delineation of sexual dimorphisms is prioritized in research. Yet any link between BCAAs and ALS remains to be fully established. While BCAAs can induce a hyperexcitability similar to the one observed in mice with ALS, current work does not show if a BCAA-enriched diet, given over a prolonged period, actually induces ALS-like symptoms. [9]

GGR senior editor Erin Chancer has also tried Watermelon Explosion. “I only used half the scoop, and there was plenty of flavor (like watermelon-infused water). I think a full scoop might be too sweet. I really liked the taste and found the mixture pleasant and refreshing.” Well, if this study, published in the International Journal for Vitamin and Nutrition Research, is anything to go by then the answer is a resounding yes. The study found that BCAA supplementation reduced delayed onset muscle soreness (DOMS) following exercise, so if you want to be able to use your arms after doing pull-ups or you want to avoid being consigned to a chair for days after doing legs then consider BCAAs. At XTEND, perfecting recovery has been our business for over 10 years. Our products do more than help you replace nutrients lost in sweat. We use science, innovation, and clinically studied ingredients to make the best BCAA products on the planet, which is why we are the category leader in BCAA.

a b c d Singh BK, Shaner DL (July 1995). "Biosynthesis of Branched Chain Amino Acids: From Test Tube to Field". The Plant Cell. 7 (7): 935–944. doi: 10.1105/tpc.7.7.935. PMC 160890. PMID 12242394. I’m not convinced the glutamine is one of them. It’s already the most abundant amino acid in the body and while it may have some benefits , it doesn’t look like it’s a potent supplement for muscle building. But it’s cheap and it’s probably beneficial for gut health, so there’s no harm in including it. Now the caveat here is how much BCAAs do you need to boost recovery and for it to really matter. And more importantly, what ratio is needed. I’ll cover that when we get to the ingredients below. Where to Buy Xtend BCAAs For optimal muscle gain, we would recommend a product with 5-8 grams of leucine throughout your workout with 1-1.5 litres of water," says Mitchell. "As leucine prolongs muscle protein synthesis after training and after meals, it can be effective for people to consume leucine 90 minutes after breakfast or lunch also, particularly where muscle gain is the goal. If you are concentrating on fat loss you can instead take it 30-45 minutes before a meal." BCAA Supplement Side Effects

SAFETY NET PRICE

Blood levels of the BCAAs are elevated in obese, insulin resistant humans and in mouse and rat models of diet-induced diabetes, suggesting the possibility that BCAAs contribute to the pathogenesis of obesity and diabetes. [10] [11] BCAA-restricted diets improve glucose tolerance and promote leanness in normal weight mice, [12] restores insulin sensitivity and normal body weight to obese mice [13] and promotes insulin sensitivity in obese rats. [14] In lean and obese mice, these benefits of BCAA-restriction are mediated by isoleucine and valine, and not by restriction of leucine. [15]